Fluconazole EP Impurity I CAS 749821-19-0
| CAS No. | 749821-19-0 |
| Molecular Formula | C13H14F2N7O |
| Molecular Weight | 322.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 322.29 g/mol gives Fluconazole EP Impurity I distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Fluconazole EP Impurity I (CAS 749821-19-0) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14F2N7O and a molecular weight of 322.29 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Fluconazole EP Impurity I is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 322.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14F2N7O |
| Molecular Weight | 322.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 7 |
Related Fluconazole Standards
- Fluconazole EP Impurity I (R-Isomer) (CAS CATO-C4X-101967)
- Fluconazole N-Oxide (CAS 1997296-62-4)
- Fluconazole Impurity 52 (CAS CATO-C4X-101952)
- Fluconazole Impurity 48 (CAS 1222655-38-0)
- Fluconazole Impurity 61 (CAS CATO-C4X-101961)
- Fluconazole Impurity 72 (CAS CATO-C4X-101972)
- Fluconazole Impurity 73 (CAS CATO-C4X-101973)
- Fluconazole EP Impurity H (CAS 150194-52-8)
Recommended Standards
- benzo[d][1,3]dioxol-5-yldiphenylphosphine oxide (CAS 209981-66-8)
- Sulfasalazine EP Impurity I (CAS 21542-82-5)
- 4-(4-Formyl-2-pyrimidinyl)phenyl 4-fluorobenzenecarboxylate (CAS 477870-91-0)
- 4-(3-Nitrobenzenesulfonamido)benzoic acid (CAS 59923-19-2)
- Iodixanol Impurity 19 (CAS 134768-69-7)
- Faropenem Impurity 11 Disodium Salt (CAS 130609-10-8)
- Baxdrostat Impurity 16 (CAS 3060412-71-4)
- 4,4,5,5,5-Pentafluoropentyl carbamimidothioate methanesulfonate (CAS 1107606-68-7)
- tert-Butyl 4-nitropiperidine-1-carboxylate (CAS 1228630-89-4)
- 4-((2,2-Difluorocyclopropyl)methoxy)benzaldehyde (CAS 1707562-77-3)
- 8-hydroxy-3,4-dihydrobenzo[b]thiepin-5(2H)-one (CAS 2226905-42-4)
- 1-tert-Butyl 2-methyl isoindoline-1,2-dicarboxylate (CAS 444607-92-5)
- 4'-Bromo-3-methyl-1,1'-biphenyl (CAS 56961-07-0)
- Semaglutide Impurity 10 (CAS CATO-C4X-222610)
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