Norfloxacin Impurity 4 CAS 75073-15-3
| CAS No. | 75073-15-3 |
| Molecular Formula | C12H9ClFNO3 |
| Molecular Weight | 269.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Norfloxacin Impurity 4 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Norfloxacin Impurity 4 (CAS 75073-15-3) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9ClFNO3 and a molecular weight of 269.66 g/mol.
Based on its molecular formula C12H9ClFNO3, Norfloxacin Impurity 4 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 269.66 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Norfloxacin Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9ClFNO3 |
| Molecular Weight | 269.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Norfloxacin Standards
- Norfloxacin Impurity C70 (CAS 106847-38-5)
- Norfloxacin Impurity C18 (CAS 70458-93-4)
- Norfloxacin EP Impurity A (CAS 68077-26-9)
- Norfloxacin Impurity 60 (CAS CATO-C4X-146860)
- Norfloxacin EP Impurity D (CAS 75001-82-0)
- Norfloxacin Impurity 52 (CAS 7251-32-3)
- Norfloxacin Impurity 59 (CAS CATO-C4X-146859)
- Norfloxacin Impurity 53 (CAS 70459-06-2)
Recommended Standards
- methyl 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylate (CAS 4415-09-2)
- Methyl 2-chloro-3-fluoro-8-methoxyquinoline-6-carboxylate (CAS 2721373-12-0)
- Pefloxacin EP Impurity H (CAS 106847-40-9)
- Ethyl 8-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (CAS 338795-20-3)
- Carfilzomib Impurity 69 (CAS CATO-C4X-102269)
- Tryptophan Impurity 44 (CAS 101948-12-3)
- Fenoterol EP Impurity B (Enantiomer Mixture) (CAS 699525-61-6)
- 2-(Piperidin-4-yl)pyridine (CAS 30532-37-7)
- [4-(Aminomethyl)piperidin-1-yl](3-fluorophenyl)methanone hydrochloride (CAS 1286273-88-8)
- Tetrabromobisphenol A Dimethyl Ether (CAS 37853-61-5)
- 5-Chloro-2-methyl-1,2-dihydro-3H-1,2,4-triazol-3-one (CAS 22354-86-5)
- N'-(3-bromo-5-methylbenzylidene)-4-methylbenzenesulfonohydrazide (CAS 2432855-03-1)
- 8-Amino-5,6-dihydro-4h-pyrrolo[3,2,1-ij]quinolin-2(1h)-one (CAS 1171377-49-3)
- 98035-79-1 Small cardioactive peptide A L-Methioninamide, L-alanyl-L-arginyl-L-prolylglycyl-L-tyrosyl-L-leucyl-L-alanyl-L-phenylalanyl-L-prolyl-L-arginyl- SCPA (CAS 98035-79-1)
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