4-ethynyl-2,6-difluoro-aniline CAS 753501-37-0
| CAS No. | 753501-37-0 |
| Molecular Formula | C8H11F2N |
| Molecular Weight | 159.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-ethynyl-2,6-difluoro-aniline (CAS 753501-37-0), a certified reference material (molecular formula C8H11F2N, MW 159.18 g/mol) for analytical method development and quality control.
Structurally, 4-ethynyl-2,6-difluoro-aniline (C8H11F2N) contains a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 159.18 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11F2N |
| Molecular Weight | 159.18 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related ethynyl Standards
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- 5-Ethynyl-2-methylbenzamide (CAS 1393901-32-0)
- 7-Ethynyl-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol (CAS 1394119-66-4)
- 3-Ethynyl-N-methylbenzamide (CAS 909293-61-4)
- 6-Ethynyl-3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 627870-75-1)
- 9-Ethynyl-9H-purin-6-amine (CAS 141299-24-3)
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Recommended Standards
- 4-Ethylmorpholine-2-carboxylic acid (CAS 939979-52-9)
- 4-Formyl-2,5-dimethylbenzonitrile (CAS 663941-24-0)
- 4-Cyclopropoxybenzonitrile (CAS 223690-05-9)
- 4-Hydroxy-1-methylpiperidine-4-carboxylic acid (CAS 757127-21-2)
- (2e)-3-{5-chloro-1-[(2,4-dichlorophenyl)methyl]-3-methyl-1h-pyrazol-4-yl}prop-2-enoic acid (CAS 956714-01-5)
- 1-Cyclobutyl-4-methyl-1H-pyrazol-5-amine (CAS 1448854-98-5)
- 1-(4-(Tert-butyl)phenyl)-2-(pyrimidin-4-yl)ethan-1-ol (CAS 849021-31-4)
- Ketoprofen Impurity 42 (CAS 76469-88-0)
- 4-(2-Bromo-4-chloro-3,5-dimethylphenoxy)-piperidine hydrochloride (CAS 1220017-85-5)
- 4-(4-Cyano-2-(2-(4-fluoronaphthalen-1-yl)propanamido)phenyl)butanoic acid (CAS 402473-54-5)
- 2-amino-N-methylbutanamide hydrochloride (CAS 51739-62-9)
- 3-Iodo-N-(3-methylpyridin-2-yl)benzamide (CAS 349118-25-8)
- [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(Diphenylamino)carbonyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic Acid Ethyl Ester (CAS 900161-12-8)
- Semaglutide Impurity 189 (CAS CATO-C4X-2226189)
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