1-Bromo-2-chloro-4,5-dimethoxybenzene CAS 753502-60-2
| CAS No. | 753502-60-2 |
| Molecular Formula | C8H8BrClO2 |
| Molecular Weight | 251.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Bromo-2-chloro-4,5-dimethoxybenzene.
CATO supplies 1-Bromo-2-chloro-4,5-dimethoxybenzene (CAS 753502-60-2), a certified reference material (molecular formula C8H8BrClO2, MW 251.50 g/mol) for analytical method development and quality control.
The molecular framework of 1-Bromo-2-chloro-4,5-dimethoxybenzene (C8H8BrClO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8BrClO2 |
| Molecular Weight | 251.50 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl/Br-containing |
Related Bromo Standards
- (5-Bromo-2-chloro-4-methoxyphenyl)methanol (CAS 1033723-31-7)
- 1-Bromo-3-chloro-2-(methoxymethoxy)benzene (CAS 1085275-89-3)
- 1-Bromo-3-chloro-2,4-dimethoxybenzene (CAS 1228956-93-1)
- 1-Bromo-2-chloro-4-(methoxymethoxy)-benzene (CAS 1300743-20-7)
- 4-Bromo-2-chloro-1-(methoxymethoxy)benzene (CAS 1301146-84-8)
- (5-Bromo-2-chloro-3-methoxyphenyl)methanol (CAS 1415467-78-5)
- 2-(5-bromo-2-chlorophenoxy)ethan-1-ol (CAS 1455206-43-5)
- 4-Bromo-1-chloro-2-(methoxymethoxy)benzene (CAS 1492151-93-5)
Recommended Standards
- 1-Bromo-2-chloro-3,5-dimethoxybenzene (CAS 81574-72-3)
- 1-Bromo-3-chloro-2,5-dimethoxybenzene (CAS 252044-83-0)
- (6-Bromo-3-chloro-2-methoxyphenyl)methanol (CAS 2090464-28-9)
- 1-Bromo-3-chloro-5-(methoxymethoxy)benzene (CAS 2023712-88-9)
- Tert-butyl (1R,2R)-2-(hydroxymethyl)cyclobutane-1-carboxylate (CAS 2137914-58-8)
- N-(2,4-Dichlorobenzylidene)-alpha,alpha,alpha-Trifluoro-m-Toluidine (CAS 91283-19-1)
- ethyl 2-(benzoylamino)-2-(diisopropoxyphosphoryl)-3,3,3-trifluoropropanoate (CAS 649550-03-8)
- 3-(2-Aminoethyl)-6-methylquinolin-2(1H)-one hydrochloride (CAS 1266693-90-6)
- N-{4-[1-(4-Fluoro-phenyl)-5-oxo-pyrrolidin-3-yl]-6-methylamino-pyrimidin-2-ylmethyl}-2-methoxy-N-methyl-acetamide hydrobromide (CAS 1361114-99-9)
- Esomeprazole Impurity 48 (CAS CATO-C4X-111248)
- 5-Acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione (CAS 338399-29-4)
- 2-(3-Hydroxy-5-(methoxycarbonyl)phenyl)acetic acid (CAS 1393540-52-7)
- 2,3-Dimethyl-1,3-benzothiazol-3-ium tetrafluoroborate (CAS 21786-62-9)
- Liraglutide Impurity 15 TFA Salt (CAS CATO-C4X-199215)
Why CATO?
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