Proparacaine Impurity 33 CAS 754936-74-8
| CAS No. | 754936-74-8 |
| Molecular Formula | C13H19ClN2O2 |
| Molecular Weight | 270.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Proparacaine Impurity 33 (CAS 754936-74-8, C13H19ClN2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Proparacaine Impurity 33 (C13H19ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Proparacaine Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19ClN2O2 |
| Molecular Weight | 270.76 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Proparacaine Standards
- Proparacaine Impurity 15 (CAS 2102411-30-1)
- Proparacaine Impurity 24 (CAS 2815508-81-5)
- Proparacaine Impurity 29 (CAS CATO-C4X-202729)
- Proparacaine Impurity 13 (CAS CATO-C4X-202713)
- Proparacaine Impurity 16 (CAS 15788-85-9)
- Proparacaine Impurity 28 (CAS 78329-81-4)
- Proparacaine Impurity 14 (CAS CATO-C4X-202714)
- Proparacaine Impurity 22 (CAS CATO-C4X-202722)
Recommended Standards
- tert-Butyl(2-(2-chloropyridin-3-yl)propan-2-yl)carbamate (CAS 2850325-50-5)
- Chloroprocaine Impurity 10 (CAS 500338-95-4)
- Tert-butyl n-[2-amino-1-(3-chlorophenyl)ethyl]carbamate (CAS 926643-36-9)
- Chloroprocaine Impurity 5 (CAS CATO-C4X-32865)
- Ritalin impurity 5 (CAS CATO-C4X-28815)
- Mirogabalin Impurity N87 (CAS 2165847-73-2)
- Tegoprazan Impurity 125 (CAS CATO-C4X-2297125)
- Glu4,Asp5,Gly9-OH-Oxytocin (CAS CATO-C4X-206612)
- 1-(2-Fluoro-3-(trifluoromethyl)phenyl)ethanone (CAS 207853-63-2)
- 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-bromobenzoic acid (CAS 1696643-67-0)
- 4-Benzyl-2-methyl-4h-furo[3,2-b]pyrrole-5-carboxylic acid (CAS 155445-43-5)
- 5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazine-3-carboxylic acid hydrochloride (CAS 1989671-91-1)
- 4,5-Dichloro-6-ethyl-2-methylpyrimidine (CAS 141602-39-3)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com