4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid CAS 756851-01-1
| CAS No. | 756851-01-1 |
| Molecular Formula | C14H8Cl2F3NO4S |
| Molecular Weight | 414.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid.
4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid (CAS 756851-01-1), molecular formula C14H8Cl2F3NO4S and molecular weight 414.18 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid (C14H8Cl2F3NO4S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-2-[4-chloro-3-(trifluoromethyl)benzenesulfonamido]benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8Cl2F3NO4S |
| Molecular Weight | 414.18 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-2-((2-chloro-5-(trifluoromethyl)phenyl)sulfonamido)benzoic acid (CAS 749896-99-9)
- (2E)-3-[5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1-(2-chloro-4-methylquinolin-3-yl)prop-2-en-1-one (CAS 400074-47-7)
- (E)-({1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1H-pyrrol-2-yl}methylidene)[(4-chlorophenyl)methoxy]amine (CAS 321430-81-3)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-carboxamide (CAS 338397-61-8)
- 2,3-Bis[3-chloro-5-(trifluoromethyl)pyridin-2-yl]propanenitrile (CAS 246022-09-3)
- 2-Chloro-N-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzenesulfonamide (CAS 338409-38-4)
- 3-Chloro-2,4-dibromo-6-fluoroiodobenzene (CAS 1000573-51-2)
- 4-Chloro-2,6-dibromo-3-fluoroiodobenzene (CAS 1160574-60-6)
Recommended Standards
- Ethyl 5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 313249-39-7)
- 2,4-Dichloro-5-{[3-(trifluoromethyl)phenyl]sulfamoyl}benzoic acid (CAS 21525-24-6)
- 2,7-Dibromospiro[fluorene-9,2'-[1,3]dithiolane] (CAS 113425-39-1)
- 3-[(4-bromophenyl)methyl]-1-methyl-7-(trifluoromethyl)-1h,2h,3h,4h-pyrido[2,3-d]pyrimidine-2,4-dione (CAS 1147522-06-2)
- Benzyl isopropyl(pyrrolidin-3-ylmethyl)carbamate (CAS 1353973-77-9)
- 7-Chloro-2,3-dihydro-1h-indole hydrochloride (CAS 1171625-52-7)
- 1-(Bromomethyl)cyclopropanecarboxylic Acid (CAS 56834-40-3)
- trans-2-(4-aminophenoxy)cyclohexan-1-ol (CAS 1820572-44-8)
- N-(4-Fluorobenzyl)-2,3-dimethylaniline (CAS 1021008-20-7)
- Prucalopride Impurity 44 (CAS CATO-C4X-103844)
- 1-Bromo-4-(1-bromopropan-2-yl)benzene (CAS 859175-02-3)
- Sodium 2-((9Z,12Z)-octadeca-9,12-dienamido)ethyl phosphate (CAS 419566-71-5)
- JWH-122 N-(5-Hydroxypentyl) metabolite (CAS 1379604-68-8)
- Anxiety Peptide (CAS 95237-86-8)
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