4-Amino-2-chloro-3-fluorobenzonitrile CAS 757247-99-7
| CAS No. | 757247-99-7 |
| Molecular Formula | C7H4ClFN2 |
| Molecular Weight | 170.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-Amino-2-chloro-3-fluorobenzonitrile (CAS 757247-99-7), molecular formula C7H4ClFN2 and molecular weight 170.57 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrile group, fluorine/chlorine substitution, an aromatic ring system, 4-Amino-2-chloro-3-fluorobenzonitrile is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 170.57 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H4ClFN2 |
| Molecular Weight | 170.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 6-Amino-3-chloro-2-fluorobenzonitrile (CAS 1000577-64-9)
- 2-Amino-4-chloro-5-fluorobenzonitrile (CAS 1015427-16-3)
- 4-Amino-2-chloro-6-fluorobenzonitrile (CAS 1095188-13-8)
- 4-Amino-3-chloro-5-fluorobenzonitrile (CAS 1147558-43-7)
- 2-Amino-5-chloro-4-fluorobenzonitrile (CAS 1217304-30-7)
- 4-Amino-2-chloro-5-fluorobenzonitrile (CAS 1228376-68-8)
- 5-Amino-2-chloro-4-fluorobenzonitrile (CAS 123614-87-9)
- 2-amino-3-chloro-5-fluorobenzonitrile (CAS 1263277-06-0)
Recommended Standards
- 3-Chloro-5-fluoro-1H-indazole (CAS 885519-10-8)
- 4-Amino-3-chloro-2-fluorobenzonitrile (CAS 2092765-25-6)
- 2-Chloro-7-fluoro-1H-benzo[d]imidazole (CAS 256519-11-6)
- 4-Chloro-6-fluoro-1H-indazole (CAS 885520-32-1)
- (Z)-5-(Fluoromethylene)-4-phenyl-1H-pyrrol-2(5H)-one (CAS 1212059-23-8)
- [1-(trifluoromethyl)pyrazol-4-yl]boronic acid (CAS 2243753-57-1)
- 6-Nitro-2h-chromene-3-carboxylic acid (CAS 923678-02-8)
- Dolutegravir Impurity 33 (CAS CATO-C4X-162033)
- Methyl 2-chlorooxazole-4-carboxylate (CAS 934236-35-8)
- 1-Fluoro-2-nitro-3-(pentan-3-yloxy)benzene (CAS 1233958-45-6)
- 4-Cyano-6-formylpyridine-2-sulfonyl chloride (CAS 1393531-13-9)
- N-(4,6-dimethylpyridin-2-yl)-3-oxobutanamide (CAS 23600-26-2)
- (5-(Thiophen-2-yl)isoxazol-3-yl)methyl 1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 1203286-63-8)
- Insulin Glargine (CAS 160337-95-1)
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