2-(4-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid CAS 75810-53-6
| CAS No. | 75810-53-6 |
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid.
CATO supplies 2-(4-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid (CAS 75810-53-6), a certified reference material (molecular formula C12H12FNO3, MW 237.23 g/mol) for analytical method development and quality control.
2-(4-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid (C12H12FNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(4-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H12FNO3 |
| Molecular Weight | 237.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorophenyl Standards
- (E)-3-(3-(2-fluorophenyl)acrylamido)propanoic acid (CAS 1098380-51-8)
- Methyl 1-(2-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (CAS 1239772-19-0)
- 2-(3-Fluorophenyl)-1-methyl-5-oxopyrrolidine-3-carboxylic acid, mixture of diastereomers (CAS 1266973-95-8)
- 1-(3-Fluorophenyl)-6-oxopiperidine-3-carboxylic acid (CAS 1285045-55-7)
- (Z)-1-(4-fluorophenyl)-N'-hydroxy-5-oxopyrrolidine-3-carboximidamide (CAS 1292229-98-1)
- Methyl 1-(4-fluorophenyl)-5-oxopyrrolidine-3-carboxylate (CAS 133747-62-3)
- 1-(2-(4-Fluorophenyl)acetyl)azetidine-3-carboxylic acid (CAS 1361113-12-3)
- (E)-3-(3-(2-Fluorophenyl)acrylamido)propanoic acid (CAS 1616611-70-1)
Recommended Standards
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- 2-Amino-2-(4-hydroxycyclohexyl)acetic acid (CAS 101252-25-9)
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- Tert-butyl (4,4-difluoropiperidin-3-yl)(methyl)carbamate (CAS 2306274-44-0)
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