Axitinib Impurity N22 CAS 7597-18-4
| CAS No. | 7597-18-4 |
| Molecular Formula | C7H5N3O2 |
| Molecular Weight | 163.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Axitinib Impurity N22 (CAS 7597-18-4) is a certified pharmaceutical impurity reference standard with the molecular formula C7H5N3O2 and a molecular weight of 163.13 g/mol.
Based on its molecular formula C7H5N3O2, Axitinib Impurity N22 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 163.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H5N3O2 |
| Molecular Weight | 163.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
| Nitrogen Atoms | 3 |
Related Axitinib Standards
- Axitinib Impurity 37 (CAS CATO-C4X-107137)
- Axitinib Impurity 13 (CAS 2527-66-4)
- Axitinib Impurity 17 (CAS 20054-45-9)
- Axitinib Impurity 66 (CAS 2419145-29-0)
- Axitinib Impurity 85 (CAS 13959-26-7)
- Axitinib Impurity 88 (CAS 87511-99-7)
- Axitinib Impurity N27 (CAS 20877-02-5)
- Axitinib Impurity 17 (CAS CATO-C4X-107117)
Recommended Standards
- 7-Nitroindazole (CAS 2942-42-9)
- Benzo[c][1,2,5]oxadiazole-4-carboxamide (CAS 408502-46-5)
- 6-Nitroimidazo[1,2-a]pyridine (CAS 25045-82-3)
- Benzo[c]isoxazole-4-carboxylic acid (CAS 716362-22-0)
- Calcitonin Impurity 4 (CAS CATO-C4X-22184)
- Cefoperazone Impurity 23 (CAS CATO-C4X-114923)
- Maribavir Impurity 16 (CAS 176161-21-0)
- Methyl O-guanidino-L-homoserinate hydrochloride (CAS 142154-80-1)
- 5-(3-Cyanobenzoyl)-2-methylpyridine (CAS 1187170-09-7)
- 1-(Difluoromethyl)-1h-pyrazole-5-carbohydrazide (CAS 1002032-57-6)
- Afatinib Impurity 16 (CAS CATO-C4X-100616)
- 2,5,6-Trimethyl-4H-thieno[3,2-b]pyrrole (CAS 830324-58-8)
- methyl 2-(4-bromophenyl)-2-chloroacetate (CAS 124573-93-9)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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