Amiloride EP Impurity C CAS 76599-74-1
| CAS No. | 76599-74-1 |
| Molecular Formula | C6H7ClN6O2 |
| Molecular Weight | 230.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Amiloride EP Impurity C (C6H7ClN6O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 230.61 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Amiloride EP Impurity C (CAS 76599-74-1, C6H7ClN6O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amiloride EP Impurity C meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN6O2 |
| Molecular Weight | 230.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Amiloride Standards
Recommended Standards
- Aprepitant impurity 52 (CAS CATO-C4X-114152)
- 1-(2,2-Difluoroethyl)-1H-pyrazole-4-sulfonyl chloride (CAS 1006487-21-3)
- Aprepitant impurity 51 (CAS CATO-C4X-114151)
- 1007874-03-4 3-chloro-3-(3-fluoro-phenyl)-2-oxo-propionic acid methyl ester (CAS 1007874-03-4)
- Paliperidone Impurity 25 (CAS CATO-C4X-172425)
- Flomoxef Impurity 53 (CAS CATO-C4X-138253)
- Letrozole Impurity 8 (CAS 2170106-13-3)
- (2,2-Dimethyl-1-(p-tolyl)cyclopropyl)methanol (CAS 884091-45-6)
- 2-(Phenylsulfonyl)naphthalene (CAS 32338-05-9)
- 3-(Chloromethyl)-4-cyclopropyl-5-methyl-4H-1,2,4-triazole Hydrochloride (CAS 1432680-03-9)
- 4,10-Diaza-12-crown 4-Ether (CAS 294-92-8)
- 2-Benzamido-N-methylbenzamide (CAS 127082-54-6)
- 7-Fluoro-1H-indazol-5-ol (CAS 1352393-98-6)
- Semaglutide impurity 268 (CAS CATO-C4X-2226268)
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