Aprepitant impurity 51 CAS CATO-C4X-114151
| CAS No. | CATO-C4X-114151 |
| Molecular Formula | C6H7ClN6O2 |
| Molecular Weight | 230.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Aprepitant impurity 51 (CAS CATO-C4X-114151), a pharmacopoeial impurity reference standard (molecular formula C6H7ClN6O2, MW 230.61 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Aprepitant impurity 51 (C6H7ClN6O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Aprepitant impurity 51 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H7ClN6O2 |
| Molecular Weight | 230.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Aprepitant Standards
- Aprepitant impurity 52 (CAS CATO-C4X-114152)
- Aprepitant impurity 50 (CAS 349-59-7)
- Aprepitant impurity 150 (CAS CATO-C4X-114150)
- Aprepitant Impurity 80 (CAS CATO-C4X-114180)
- Aprepitant Impurity 34 (CAS 30071-93-3)
- Aprepitant Impurity 75 (CAS 240489-98-9)
- Aprepitant impurity 28 (CAS 479679-98-6)
- Aprepitant Impurity 32 (CAS 225920-05-8)
Recommended Standards
- n-(4-Chloro-6-methyl-5-nitropyrimidin-2-yl)acetamide (CAS 728935-39-5)
- N-(2-Chloro-5-hydroxy-4-nitrophenyl)acetamide (CAS 2092000-50-3)
- Amiloride EP Impurity C (CAS 76599-74-1)
- Methyl 4-amino-3-chloro-5-nitrobenzoate (CAS 863886-04-8)
- Itopride Impurity 20 (CAS 131028-54-1)
- Bumetanide Impurity 128 (CAS CATO-C4X-1986128)
- Avatrombopag Impurity 59 (CAS 2948773-23-5)
- 1-(4-Fluorophenyl)-1H-pyrrole-2,5-dione (CAS 6633-22-3)
- Benzoic acid, 3-(methoxymethoxy)-, 2,5-dioxo-1-pyrrolidinyl ester (CAS 1560874-18-1)
- N-methyl-N'-(azide-PEG3)-Cy3 (CAS 2107273-16-3)
- (3-fluoropyrazin-2-yl)methanol (CAS 2169065-16-9)
- N-Hydroxy-3-methoxyisoxazole-5-carboximidamide (CAS 468067-96-1)
- 1-Bromo-4-(4-chlorophenyl)butan-2-one (CAS 143327-55-3)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com