Paliperidone Impurity 59 CAS 766485-15-8
| CAS No. | 766485-15-8 |
| Molecular Formula | C23H23FN4O3 |
| Molecular Weight | 422.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Paliperidone Impurity 59 (CAS 766485-15-8, C23H23FN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Paliperidone Impurity 59 (C23H23FN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C23H23FN4O3 |
| Molecular Weight | 422.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Paliperidone Standards
- Paliperidone Impurity 87 (CAS CATO-C4X-172487)
- Paliperidone Impurity 11 (CAS 531524-17-1)
- Paliperidone Impurity 1 （Mixture of Tautomeric Isomers） (CAS 1189516-65-1)
- Paliperidone Impurity 69 (CAS CATO-C4X-172469)
- Paliperidone Impurity 26 (CAS CATO-C4X-172426)
- Paliperidone Impurity 12 (CAS CATO-C4X-172412)
- Paliperidone Impurity 97 (CAS CATO-C4X-172497)
- Paliperidone (CAS 144598-75-4)
Recommended Standards
- Olaparib Impurity 17 (CAS CATO-C4X-113517)
- N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)-2-[[3-cyano-6-methyl-4-(trifluoromethyl)-2-pyridinyl]thio]acetamide (CAS 625369-63-3)
- Bumetanide Impurity 131 (CAS CATO-C4X-1986131)
- N-(3,4-difluorophenyl)-2-((4,5-diphenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 436842-77-2)
- Nabumetone impurity 30 (CAS 3003868-26-3)
- Cefuroxime Dimer Impurity 42 (CAS CATO-C4X-124542)
- Posaconazole Impurity 173 (CAS CATO-C4X-1208173)
- Ethyl 2-amino-3-hydroxybenzoate (CAS 606-13-3)
- 9-Chloro-5-methyl-5H-thiochromeno[4,3-d]pyrimidin-2-amine (CAS 254429-65-7)
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-bromo-6-methylpyridin-3-yl)boronate (CAS 1309981-30-3)
- Methyl 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxylate (CAS 147137-38-0)
- 6-(3,4-Dichloro-benzyl)-3-thioxo-3,4-dihydro-2H-[1,2,4]triazin-5-one (CAS 571150-97-5)
- 5-Chloro-3-ethyl-3-methyl-3,4-dihydro-2H-[1,3'-biquinolin]-2-one (CAS 918646-18-1)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
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