Paliperidone Impurity 1 （Mixture of Tautomeric Isomers） CAS 1189516-65-1
| CAS No. | 1189516-65-1 |
| Molecular Formula | C23H25FN4O3 |
| Molecular Weight | 424.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Paliperidone Impurity 1 （Mixture of Tautomeric Isomers） (CAS 1189516-65-1, C23H25FN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Paliperidone Impurity 1 （Mixture of Tautomeric Isomers） is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 424.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Paliperidone Impurity 1 （Mixture of Tautomeric Isomers） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H25FN4O3 |
| Molecular Weight | 424.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Paliperidone Standards
- Paliperidone Impurity 69 (CAS CATO-C4X-172469)
- Paliperidone Impurity 26 (CAS CATO-C4X-172426)
- Paliperidone Impurity 12 (CAS CATO-C4X-172412)
- Paliperidone Impurity 97 (CAS CATO-C4X-172497)
- Paliperidone (CAS 144598-75-4)
- Paliperidone Impurity 40 (CAS CATO-C4X-1724140)
- Paliperidone Impurity 35 (CAS 1346598-34-2)
- Paliperidone Impurity 59 (CAS 766485-15-8)
Recommended Standards
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- (2R,5S)-Lamivudine Impurity 33 (CAS 147027-10-9)
- Desmopressin Impurity 40 (CAS CATO-C4X-221540)
- Isepamicin Impurity 12 (CAS CATO-C4X-311112)
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- 4-Ethyl-5-morpholino-4H-1,2,4-triazole-3-thiol (CAS 847783-74-8)
- 2-[[(Tetrahydropyran-2-yl)oxy]methyl]benzaldehyde (CAS 99948-47-7)
- 2-(2-Methoxyethoxy)ethyl acetate (CAS 629-38-9)
- 2-(Aminomethyl)-3-(difluoromethyl)-4-methylpyridine-6-methanol (CAS 1805071-89-9)
- 3-(2-Methoxyphenyl)-1-(piperazin-1-yl)propan-1-one hydrochloride (CAS 1266690-36-1)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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