Flecainide Impurity 18 CAS 76784-40-2
| CAS No. | 76784-40-2 |
| Molecular Formula | C12H10F6O3 |
| Molecular Weight | 316.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Flecainide Impurity 18 (CAS 76784-40-2), a pharmacopoeial impurity reference standard (molecular formula C12H10F6O3, MW 316.20 g/mol) used for the identification and quantification of trace impurities in APIs.
Flecainide Impurity 18 (C12H10F6O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C12H10F6O3 |
| Molecular Weight | 316.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
Related Flecainide Standards
Recommended Standards
- Ethyl 4,8-dichloro-2-(methylthio)quinoline-3-carboxylate (CAS 662138-33-2)
- Methyl (Methyl 3-Deoxy-D-arabino-heptulopyranosid)onate-7-Phosphate (CAS 91382-80-8)
- Ethyl 4,6-dichloro-2-(methylthio)quinoline-3-carboxylate (CAS 227958-96-5)
- Methyl 2-amino-4-(2,4-dichlorophenyl)-5-methylthiophene-3-carboxylate (CAS 350989-98-9)
- Tirzepatide Impurity 21 X TFA Salt (CAS CATO-C4X-324021)
- Telmisartan Impurity 96 (CAS CATO-C4X-135996)
- Linezolid Impurity 56 (CAS 725676-93-7)
- 7-(3-Methyl-1H-pyrazol-1-yl)-3-phenyl-2H-chromen-2-one (CAS 34742-12-6)
- 3-Cyclopropoxy-N2,N2,N6,N6-tetramethylpyridine-2,6-diamine (CAS 1243467-78-8)
- Imino(methyl)(thiophen-2-yl)-l6-sulfanone (CAS 145026-08-0)
- ethyl 3,3,3-trifluoro-2-hydroxy-2-[(2,2,2-trifluoroacetyl)amino]propanoate (CAS 329182-36-7)
- 2-Ethyl-5-phenylbenzo[d]oxazole (CAS 402745-81-7)
- (S)-5-Oxopiperazine-2-carboxylic acid (CAS 135630-97-6)
- Semaglutide Impurity 137 (x TFA Salt) (CAS CATO-C4X-2226137)
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