Fexofenadine EP Impurity A CAS 76811-98-8
| CAS No. | 76811-98-8 |
| Molecular Formula | C32H37NO4 |
| Molecular Weight | 499.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 499.64 g/mol gives Fexofenadine EP Impurity A distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Fexofenadine EP Impurity A (CAS 76811-98-8, C32H37NO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fexofenadine EP Impurity A (C32H37NO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fexofenadine EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C32H37NO4 |
| Molecular Weight | 499.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Nitrogen Atoms | 1 |
Related Fexofenadine Standards
- Fexofenadine Impurity 13 (CAS 1010812-98-2)
- Fexofenadine Impurity 28 (CAS CATO-C4X-179428)
- (R)-Fexofenadine (CAS 139965-10-9)
- (S)-Fexofenadine (CAS 139965-11-0)
- Fexofenadine EP Impurity B (CAS 479035-75-1)
- Fexofenadine (CAS 83799-24-0)
- Fexofenadine-D6 (CAS 548783-71-7)
- Fexofenadine EP Impurity F (CAS 185066-33-5)
Recommended Standards
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- 4-bromo-2-tert-butyl-6-nitrophenol (CAS 150313-84-1)
- 80907-56-8 Tris(2,2'-bipyrazine)ruthenium(II) hexafluorophosphate, 95% MFCD27952557 (CAS 80907-56-8)
- Insulin Degludec Impurity 2 (CAS CATO-C4X-21572)
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