N-(4-Chloro-2-methylphenyl)-2-hydroxybenzamide CAS 77067-91-5
| CAS No. | 77067-91-5 |
| Molecular Formula | C14H12ClNO2 |
| Molecular Weight | 261.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-(4-Chloro-2-methylphenyl)-2-hydroxybenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-(4-Chloro-2-methylphenyl)-2-hydroxybenzamide (CAS 77067-91-5), molecular formula C14H12ClNO2 and molecular weight 261.70 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, N-(4-Chloro-2-methylphenyl)-2-hydroxybenzamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 261.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H12ClNO2 |
| Molecular Weight | 261.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-(3-CHloro-4-methylphenyl)-4-hydroxybenzamide (CAS 1019378-55-2)
- N-(3-CHloro-2-methylphenyl)-3-hydroxybenzamide (CAS 1019379-60-2)
- N-(2-CHloro-4-methylphenyl)-4-hydroxybenzamide (CAS 1039984-70-7)
- N-(2-CHloro-4-methylphenyl)-3-hydroxybenzamide (CAS 1040071-77-9)
- 5-Chloro-1-(4-methylbenzyl)-6-oxo-1,6-dihydropyridine-3-carbaldehyde (CAS 1048913-54-7)
- 3-Chloro-N-(2,4-difluorobenzyl)-2,2-dimethylpropanamide (CAS 134672-77-8)
- Methyl 5-(5-chloro-2-methylphenyl)picolinate (CAS 1415129-66-6)
- 3-Chloro-N-(4-methoxyphenyl)benzamide (CAS 158525-81-6)
Recommended Standards
- N-(4-(2-chlorophenoxy)phenyl)acetamide (CAS 915879-09-3)
- N-(4-Chlorophenyl)-2-methoxybenzamide (CAS 54979-74-7)
- N-(3-Chlorophenyl)-2-methoxybenzamide (CAS 54979-76-9)
- N-(4-chlorophenyl)-3-methoxybenzamide (CAS 96776-05-5)
- 5-Amino-2-methyl-9,10-dihydroacridin-9-one (CAS 893612-42-5)
- 2-Chloro-5-(morpholine-4-sulfonyl)aniline (CAS 99187-74-3)
- 2-[(2,4-difluorophenyl)formamido]acetic acid (CAS 918157-04-7)
- tert-Butyl 2-(3-aminophenyl)acetate (CAS 183180-53-2)
- 3-Amino-4,5-dimethoxybenzoic Acid (CAS 861556-80-1)
- 2-Methyl-4-cyclopropylanisole (CAS 81484-44-8)
- N-methoxy-N-methyl-1,3-benzodioxole-5-carboxamide (CAS 147030-72-6)
- Benzofuran-7-yl (2,4-dimethoxyphenyl)carbamate (CAS 94242-01-0)
- 1-benzyl-4-ethylpyrrolidine-3-carboxylic acid hydrochloride (CAS 2044713-33-7)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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