Methylprednisolone Hydrogen Succinate EP Impurity B CAS 77074-42-1
| CAS No. | 77074-42-1 |
| Molecular Formula | C26H34O8 |
| Molecular Weight | 474.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Methylprednisolone Hydrogen Succinate EP Impurity B (CAS 77074-42-1), a pharmacopoeial impurity reference standard (molecular formula C26H34O8, MW 474.54 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Methylprednisolone Hydrogen Succinate EP Impurity B (C26H34O8) contains a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 474.54 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Methylprednisolone Hydrogen Succinate EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C26H34O8 |
| Molecular Weight | 474.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
Related Methylprednisolone Standards
- Methylprednisolone Hydrogen Succinate EP Impurity F (CAS 2376134-25-5)
- Methylprednisolone Impurity 3 (CAS CATO-C4X-19193)
- Methylprednisolone 21-Hemisuccinate (Methylprednisolone Hydrogen Succinate) (CAS 2921-57-5)
- Methylprednisolone impurity 96 (CAS 103302-98-3)
- Methylprednisolone Impurity 52 (CAS CATO-C4X-191952)
- Methylprednisolone Impurity 49 (CAS CATO-C4X-191949)
- Methylprednisolone Impurity 1 (CAS CATO-C4X-19191)
- Methylprednisolone Impurity 78 (CAS CATO-C4X-191978)
Recommended Standards
- Canagliflozin Impurity 30 (CAS 1358581-37-9)
- Canagliflozin impurity 119 (CAS CATO-C4X-1123119)
- Canagliflozin Impurity 111 (CAS CATO-C4X-1123111)
- Saterinone (CAS 102669-89-6)
- Imatinib Impurity 85 (CAS 909342-95-6)
- Azathioprine EP Impurity B (CAS 50-44-2)
- Ramosetron Impurity 25 (CAS CATO-C4X-118225)
- 5-bromothieno[2,3-b]pyridine (CAS 21344-24-1)
- tert-Butyl 2-chloro-5h,6h,7h-pyrrolo[3,4-b]pyridine-6-carboxylate (CAS 1257854-60-6)
- 5-(1,3-Dioxolan-2-yl)-2-(4-nitrobenzoyl)thiophene (CAS 898778-34-2)
- (3S,5R)-1-(tert-butoxycarbonyl)-5-(methoxycarbonyl)pyrrolidine-3-carboxylic acid (CAS 2306246-06-8)
- Pcb No. 194 (CAS 35694-08-7)
- tert-Butyl 3-methyl-2,8-diazaspiro[4.5]decane-8-carboxylate (CAS 1899102-29-4)
- Semaglutide impurity 40 (CAS CATO-C4X-222640)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com