3-Chloro-6-methyl-4-nitropyridazine CAS 771-78-8
| CAS No. | 771-78-8 |
| Molecular Formula | C5H4ClN3O3 |
| Molecular Weight | 189.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-6-methyl-4-nitropyridazine (C5H4ClN3O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
3-Chloro-6-methyl-4-nitropyridazine (CAS 771-78-8), molecular formula C5H4ClN3O3 and molecular weight 189.56 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClN3O3 |
| Molecular Weight | 189.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-Chloro-n-methyl-n-(2,2,2-trifluoroethyl)acetamide (CAS 1179829-40-3)
- 4-Chloro-2-methoxy-5-nitropyrimidine (CAS 1375065-27-2)
- 2-Chloro-n-(2,2,2-trifluoroethyl)propanamide (CAS 139126-57-1)
- 2-Chloro-1-(4-nitro-1H-imidazol-1-yl)ethanone (CAS 59566-56-2)
- 2-chloro-4-methoxy-5-nitro-pyrimidine (CAS 282102-07-2)
- 2-Chloro-5-nitropyrimidine-4,6-diamine (CAS 408352-74-9)
- 2-Chloro-6-methyl-5-nitropyrimidin-4(1H)-one (CAS 65224-66-0)
- 4-Chloro-6-methoxy-5-nitropyrimidine (CAS 52854-14-5)
Recommended Standards
- 6-Chloro-2-methyl-5-nitropyrimidin-4(3H)-one (CAS 82779-50-8)
- Methyl 4-(chlorocarbonyl)-1H-1,2,3-triazole-5-carboxylate (CAS 488816-89-3)
- N-(3-chloropropyl)-2,2,2-trifluoroacetamide (CAS 67680-78-8)
- 2,4-Diamino-6-chloro-5-nitropyrimidine (CAS 6036-64-2)
- 5-Oxopyrazolidine-3-carbohydrazide (CAS 344947-82-6)
- Methyl 2-bromo-4-fluoro-5-hydroxybenzoate (CAS 1357147-45-5)
- Allyl(2-isopropylphenyl)sulfane (CAS 73059-75-3)
- (R)-N-Butyl-2-(3-hydroxypyrrolidin-1-yl)acetamide (CAS 1355623-32-3)
- 2-(8-Quinolyl)ethanamine (CAS 910381-50-9)
- Upadacitinib Impurity 213 (CAS 2768445-19-6)
- 2-Amino-1-(4-hydroxyphenyl)-4,5-dimethyl-1h-pyrrole-3-carbonitrile (CAS 929974-41-4)
- 2-(2-Bromopropyl)-3-fluoropyridine (CAS 1338984-77-2)
- 1-(4-Aminophenyl)pyrrolidin-2-one hydrochloride (CAS 1956354-60-1)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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