5,6-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride CAS 77141-34-5
| CAS No. | 77141-34-5 |
| Molecular Formula | C12H15NO4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5,6-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (CAS 77141-34-5), molecular formula C12H15NO4HCl and molecular weight 273.71 g/mol, is a CATO reference standard with documented purity and traceability.
5,6-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride (C12H15NO4HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H15NO4 HCl |
| Molecular Weight | 273.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dimethoxy Standards
- 6,7-Dimethoxy-1,4-phthalazinediol (CAS 10001-35-1)
- 6,7-Dimethoxy-4-methylphthalazin-1(2H)-one (CAS 10001-36-2)
- 3-Benzyl-9,9-dimethoxy-3-azabicyclo[3.3.1]nonane (CAS 1000931-10-1)
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Recommended Standards
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- 2-(3-Bromophenyl)-2-methyloxetane (CAS 850348-58-2)
- 1-[(E)-2-(2-Chlorophenyl)ethenyl]-3-[(2-methoxyphenyl)methyl]urea (CAS 400082-43-1)
- Vialox Peptide(Pentapeptide-3) (CAS 135679-88-8)
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