Chlorphenamine Impurity 7 CAS 78180-89-9
| CAS No. | 78180-89-9 |
| Molecular Formula | C16H19ClN2O |
| Molecular Weight | 290.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Chlorphenamine Impurity 7 (CAS 78180-89-9, C16H19ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Chlorphenamine Impurity 7 (C16H19ClN2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 290.79 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C16H19ClN2O |
| Molecular Weight | 290.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorphenamine Standards
- Chlorphenamine impurity 54 (CAS CATO-C4X-118854)
- Chlorphenamine impurity 57 (CAS CATO-C4X-118857)
- Chlorphenamine EP Impurity A (CAS 1246816-57-8)
- Chlorphenamine Impurity 73 (CAS CATO-C4X-118873)
- Chlorphenamine EP Impurity D (CAS 65676-21-3)
- Chlorphenamine Impurity 46 (CAS CATO-C4X-118846)
- Chlorphenamine impurity 50 (CAS CATO-C4X-118850)
- Chlorphenamine Impurity 62 (CAS CATO-C4X-118862)
Recommended Standards
- S-Chlorpheniramine N-0xide (CAS 142494-46-0)
- 3-(4-tert-Butylphenoxy)propane-1-sulfonyl chloride (CAS 1018288-96-4)
- 3-[3-Methyl-4-(propan-2-yl)phenoxy]propane-1-sulfonyl chloride (CAS 1018549-08-0)
- Chlorpheniramine Impurity 15 (CAS 120244-82-8)
- Latamoxef Impurity 4 (CAS 76945-69-2)
- Tetrabenazine Impurity 14 (CAS 2070924-91-1)
- Etrasimod Impurity 33 (CAS 131373-89-2)
- 2-Chloro-3-(3-chlorophenyl)-1-propene (CAS 731772-04-6)
- 2-[(2,5-Dichlorophenyl)sulfanyl]-3-phenylquinoline (CAS 339013-96-6)
- n-Methyl-2-(1h-1,2,4-triazol-3-yl)ethan-1-amine (CAS 34392-55-7)
- 1-(2-Amino-1-(m-tolyl)ethyl)pyrrolidine-3-carboxylicacidhydrochloride (CAS 1958100-65-6)
- 2,4-Dichloro-6-fluorobenzotrifluoride (CAS 1806329-34-9)
- (4-(3-Methyl-1,2,4-oxadiazol-5-yl)phenyl)methanamine (CAS 1036532-71-4)
- Des-Lys16-Tirzepatide (CAS CATO-CPTD788957)
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