Ethyl 4-chloro-8-cyanoquinoline-3-carboxylate CAS 77173-67-2
| CAS No. | 77173-67-2 |
| Molecular Formula | C13H9ClN2O2 |
| Molecular Weight | 260.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Ethyl 4-chloro-8-cyanoquinoline-3-carboxylate (CAS 77173-67-2), a certified reference material (molecular formula C13H9ClN2O2, MW 260.68 g/mol) for analytical method development and quality control.
Ethyl 4-chloro-8-cyanoquinoline-3-carboxylate (C13H9ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Ethyl 4-chloro-8-cyanoquinoline-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9ClN2O2 |
| Molecular Weight | 260.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
- 10-Chloro-3,4-dihydro-2h-[1,4]dioxepino[2,3-g]quinoline-9-carbonitrile (CAS 1017037-61-4)
- 1-(3-Chloro-2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (CAS 1082419-78-0)
- 6-Chloro-3-(2-methoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1096984-21-2)
- Methyl 6-chloro-9H-pyrido[3,4-b]indole-3-carboxylate (CAS 110522-03-7)
- 3-Chloro-N-(4-cyano-1-methyl-1H-pyrazol-5-yl)benzamide (CAS 1171323-74-2)
- 2-(4-Chloro-1H-pyrazol-1-yl)-N-(4-cyanophenyl)acetamide (CAS 1178331-17-3)
- 2-(4-Chloro-1h-pyrazol-1-yl)-N-(3-cyanophenyl)acetamide (CAS 1178454-95-9)
- 5-Chloro-2-(4-methoxyphenyl)oxazolo[5,4-b]pyridine (CAS 1201324-13-1)
Recommended Standards
- Ethyl 4-chloro-6-cyanoquinoline-3-carboxylate (CAS 403841-76-9)
- methyl 1-(3-chloro-2-cyanophenyl)-1H-pyrrole-2-carboxylate (CAS 866042-56-0)
- Ethyl 4-chloro-3-cyanoquinoline-6-carboxylate (CAS 872577-51-0)
- Methyl 4-chloropyrrolo[1,2-a]quinoxaline-7-carboxylate (CAS 2842028-56-0)
- (S)-2-Chloro-1-(3-chlorophenyl)ethanol (CAS 174699-78-6)
- 6-Methoxy-2H-chromene (CAS 18385-84-7)
- Chloropentamethyldisilane (CAS 1560-28-7)
- n-(2-Fluorophenyl)-2-(piperazin-1-yl)acetamide dihydrochloride (CAS 1365836-41-4)
- 5-(Hydroxyimino)-7-(piperidin-1-ylmethyl)quinolin-8(5H)-one dihydrochloride (CAS 1282459-30-6)
- Siloxanes and Silicones, di-Me, Me 3,3,3-trifluoropropyl, vinyl group-terminated (CAS 68951-98-4)
- 5-Bromo-6-fluoro-1,3-dimethyl-1H-indazole (CAS 929885-09-6)
- 2-Butyl-2-Ethyl-1,3-Propanediol (CAS 115-84-4)
- ((4-Methoxyphenyl)sulfonyl)-L-phenylalanine (CAS 51866-90-1)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com