2-Fluoro-4-(trifluoromethyl)phenol CAS 77227-78-2
| CAS No. | 77227-78-2 |
| Molecular Formula | C7H4F4O |
| Molecular Weight | 180.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Fluoro-4-(trifluoromethyl)phenol.
2-Fluoro-4-(trifluoromethyl)phenol (CAS 77227-78-2), molecular formula C7H4F4O and molecular weight 180.10 g/mol, is a CATO reference standard with documented purity and traceability.
2-Fluoro-4-(trifluoromethyl)phenol (C7H4F4O) contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-4-(trifluoromethyl)phenol meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F4O |
| Molecular Weight | 180.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 1-Fluoro-3-(trifluoromethoxy)benzene (CAS 1077-01-6)
- 3-Fluoro-6-(trifluoromethyl)pyridin-2-amine (CAS 1214330-82-1)
- 5-Fluoro-3-(trifluoromethyl)pyridin-2-amine (CAS 1214372-02-7)
- 3-Fluoro-4-(trifluoromethyl)-2-pyridinamine (CAS 1227514-27-3)
- 5-Fluoro-6-trifluoromethyl-pyridin-2-ylamine (CAS 1227602-80-3)
- 5-Fluoro-2-(trifluoromethyl)pyridin-3-amine (CAS 1245913-23-8)
- 4-Fluoro-2-(trifluoromethyl)phenol (CAS 130047-19-7)
- 2-Fluoro-5-(trifluoromethyl)phenol (CAS 141483-15-0)
Recommended Standards
- 2-Amino-3-fluoro-5-trifluoromethylpyridine (CAS 852062-17-0)
- 2-Fluoro-5-(trifluoromethyl)pyridin-3-amine (CAS 72600-65-8)
- 2,3,5,6-Tetrafluorophenylhydrazine (CAS 653-11-2)
- 2-Fluoro-6-(trifluoromethyl)phenol (CAS 239135-50-3)
- 2-(7-Oxo-5,8-diazaspiro[3.4]oct-6-yl)benzoic Acid (CAS 1272755-83-5)
- 850814-34-5 A10205 ethyl 4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate ethyl4-hydroxy-1-isopentyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate (CAS 850814-34-5)
- 4-(Chloromethyl)-1H-indazole hydrochloride (CAS 1956307-11-1)
- 3-Oxobutanoyl chloride (CAS 39098-85-6)
- Furo[3,2-c]quinolin-4(5H)-one (CAS 35136-12-0)
- 2-bromo-4-chlorobenzene-1-sulfonyl chloride (CAS 929281-63-0)
- Di-tert-butyl (S)-3-(hydroxymethyl)tetrahydropyridazine-1,2-dicarboxylate (CAS 1633022-18-0)
- tert-Butyl 2-(4-((tert-butoxycarbonyl)amino)-5-oxopyrazolidin-1-yl)acetate (CAS 140182-12-3)
- Methyl 3-((trimethylsilyl)oxy)but-2-enoate (CAS 62269-44-7)
- Semaglutide Impurity 144 (CAS 394210-59-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com