4-chloro-2-methyl-6-(p-tolyl)pyrimidine CAS 77232-27-0
| CAS No. | 77232-27-0 |
| Molecular Formula | C12H11ClN2 |
| Molecular Weight | 218.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-chloro-2-methyl-6-(p-tolyl)pyrimidine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-chloro-2-methyl-6-(p-tolyl)pyrimidine (CAS 77232-27-0), a certified reference material (molecular formula C12H11ClN2, MW 218.68 g/mol) for analytical method development and quality control.
4-chloro-2-methyl-6-(p-tolyl)pyrimidine (C12H11ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-chloro-2-methyl-6-(p-tolyl)pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11ClN2 |
| Molecular Weight | 218.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related chloro Standards
- 4-Benzyl-6-chloro-2-methylpyrimidine (CAS 100565-30-8)
- 4-Chloro-1-(2,2-diethoxyethyl)-1h-pyrazole (CAS 1006334-37-7)
- 2-Chloro-N-(pyridin-4-ylmethyl)aniline (CAS 1019552-09-0)
- 2-Chloro-N-(pyridin-3-ylmethyl)aniline (CAS 1019624-08-8)
- 6-Chloro-4,4'-dimethyl-2,2'-bipyridine (CAS 1025763-34-1)
- methyl 6-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate (CAS 1083196-33-1)
- (2'-Chloro-[1,1'-biphenyl]-4-yl)methanol (CAS 109524-03-0)
- 4-Chloro-2-cyclobutylquinazoline (CAS 1095559-57-1)
Recommended Standards
- 4-(Chloromethyl)-4'-methyl-2,2'-bipyridyl (CAS 83799-54-6)
- 4'-Chloro-3-methoxy-1,1'-biphenyl (CAS 66175-36-8)
- 4-(4-Chlorobenzyl)phenol (CAS 52890-73-0)
- (4'-Chloro-[1,1'-biphenyl]-4-yl)methanol (CAS 22494-48-0)
- (2E,4E)-dodeca-2,4-dien-1-ol (CAS 18485-38-6)
- 4-Chloro-6-methoxy-3-(1H)indazole carboxaldehyde (CAS 885520-41-2)
- N-Methyl-4,5-dihydro-1,3-thiazol-2-amine (CAS 10416-51-0)
- 4-((((9h-Fluoren-9-yl)methoxy)carbonyl)amino)-3-chlorobenzoic acid (CAS 1301628-43-2)
- tetrahydro-N-(tetrahydro-1,1-dioxido-3-thienyl)-2-Furanmethanamine, hydrochloride (1:1) (CAS 1052418-36-6)
- 2-Amino-4-(tert-butyl)-5-chlorophenol (CAS 2648339-20-0)
- 2-(DIETHYLAMINO)-2-METHYLPROPAN-1-OL (CAS 25688-63-5)
- Dropropizine N-Oxide (CAS 152323-00-7)
- [cis-3-Fluoro-4-piperidyl]methanol (CAS 895634-73-8)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com