(2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid CAS 773111-09-4

Purity 97%+In StockPharmaceutical Standards
CAS No.773111-09-4
Molecular FormulaC10H8ClFO2
Molecular Weight214.62 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

(2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid CAS 773111-09-4 chemical structure

Description

The occurrence of (2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

CATO supplies (2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid (CAS 773111-09-4), a certified reference material (molecular formula C10H8ClFO2, MW 214.62 g/mol) for analytical method development and quality control.

The molecular framework of (2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid (C10H8ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), (2E)-3-(4-Chloro-3-fluorophenyl)-2-methylprop-2-enoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H8ClFO2
Molecular Weight214.62 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1986
Halogen ContentF/Cl-containing

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