Ethyl 5-fluoro-2-(trifluoromethyl)benzoate CAS 773135-32-3
| CAS No. | 773135-32-3 |
| Molecular Formula | C10H8F4O2 |
| Molecular Weight | 236.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Ethyl 5-fluoro-2-(trifluoromethyl)benzoate (CAS 773135-32-3) is a high-purity analytical reference standard with the molecular formula C10H8F4O2 and a molecular weight of 236.16 g/mol.
The molecular framework of Ethyl 5-fluoro-2-(trifluoromethyl)benzoate (C10H8F4O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8F4O2 |
| Molecular Weight | 236.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
Related Ethyl Standards
- 1-[3-Fluoro-4-(2,2,2-trifluoroethoxy)-phenyl]-ethanone (CAS 1019528-63-2)
- Ethyl 3-fluoro-2-(trifluoromethyl)benzoate (CAS 1214376-17-6)
- 1-(3-Fluoro-4-(trifluoromethoxy)phenyl)propan-1-one (CAS 1261616-43-6)
- 2-(2-Fluoro-5-methyl-4-(trifluoromethyl)phenyl)acetic acid (CAS 1323966-46-6)
- 2-(4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)acetic acid (CAS 1373920-82-1)
- 4-Fluoro-2-(2-(trifluoromethyl)oxetan-2-yl)phenol (CAS 1402004-66-3)
- 7-Fluoro-8-nitroquinoline-4-carboxylic acid (CAS 1420790-73-3)
- 8-Fluoro-5-nitroquinoline-2-carboxylic acid (CAS 1420791-58-7)
Recommended Standards
- Ethyl 3-fluoro-5-(trifluoromethyl)benzoate (CAS 250682-12-3)
- Methyl 2-(3-fluoro-4-(trifluoromethyl)phenyl)acetate (CAS 300355-64-0)
- Ethyl 3-fluoro-4-(trifluoromethyl)benzoate (CAS 773135-31-2)
- Methyl 2-(3-fluoro-5-(trifluoromethyl)phenyl)acetate (CAS 955036-78-9)
- Methyl 5-isopropyl-4,5-dihydroisoxazole-3-carboxylate (CAS 147008-05-7)
- tert-Butyl (2-(cyanomethyl)phenyl)carbamate (CAS 1238507-98-6)
- 1,6-Naphthyridine-5-carboximidamide hydrochloride (CAS 1179360-47-4)
- Milnacipran Impurity 11 (CAS CATO-C4X-103311)
- 7-Bromo-2-phenyl-[1,2,4]triazolo[1,5-a]pyridine (CAS 1380331-12-3)
- N-tert-Butoxycarbonyl-4-[2-(4-toluenesulfonyloxy)ethyl]piperidine (CAS 89151-45-1)
- 2-(tert-Butoxy)-4-cyclopropoxy-1-fluorobenzene (CAS 1243462-05-6)
- Isoxazole-3-carbonitrile (CAS 68776-57-8)
- (R)-Benzyl 3-(aminomethyl)pyrrolidine-1-carboxylate hydrochloride (CAS 1217726-65-2)
- Liraglutide Impurity 10 TFA Salt (CAS CATO-C4X-199210)
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