Methyl 6-chloro-2-fluoro-3-methylbenzoate CAS 773874-01-4
| CAS No. | 773874-01-4 |
| Molecular Formula | C9H8ClFO2 |
| Molecular Weight | 202.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 6-chloro-2-fluoro-3-methylbenzoate.
Methyl 6-chloro-2-fluoro-3-methylbenzoate (CAS 773874-01-4), molecular formula C9H8ClFO2 and molecular weight 202.61 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Methyl 6-chloro-2-fluoro-3-methylbenzoate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8ClFO2 |
| Molecular Weight | 202.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
Related Methyl Standards
- 2-(2-Chloro-4-fluoro-5-methylphenyl)acetic acid (CAS 1000522-29-1)
- 2-Chloro-1-(2-fluoro-4-methoxyphenyl)ethan-1-one (CAS 1028298-97-6)
- Methyl 2-(2-chloro-6-fluorophenyl)acetate (CAS 103473-99-0)
- Methyl 2-(4-chloro-3-fluorophenyl)acetate (CAS 1035262-89-5)
- Methyl 2-chloro-2-(4-fluorophenyl)acetate (CAS 1036273-29-6)
- 3-Chloro-1-(5-fluoro-2-hydroxyphenyl)propan-1-one (CAS 104147-77-5)
- 2-(2-Chloro-6-fluorophenyl)propanoic acid (CAS 1083172-73-9)
- 6- Chloro- 2- (ethylamino) pyridine- 3- carbonyl Fluoride (CAS 1092523-22-2)
Recommended Standards
- Methyl 2-chloro-6-fluoro-3-methylbenzoate (CAS 773874-00-3)
- N-(2-Amino-5-chloro-4-fluoro-phenyl)-acetamide (CAS 218456-61-2)
- Methyl 2-chloro-2-(2-fluorophenyl)acetate (CAS 90055-51-9)
- N-(4-Amino-2-chloro-6-fluorophenyl)acetamide (CAS 218929-90-9)
- 2'-Amino-4',5'-methylenedioxyacetophenone hydrochloride (CAS 93983-01-8)
- 4,6-Dimethoxy-2-methylpyrimidin-5-amine (CAS 77296-23-2)
- N,N-Diallyl-2-pyrrolidinecarboxamide hydrochloride (CAS 1246172-86-0)
- 5-(3-hydroxyphenyl)pentanoic acid (CAS 31129-95-0)
- 3-(4,6-Dichloro-1H-indol-3-yl)propan-1-amine hydrochloride (CAS 1956376-29-6)
- 4,4'-(1,1,3,3-Tetramethyldisiloxane-1,3-diyl)bis(butan-1-ol) (CAS 5931-17-9)
- 4-Chloro-2-ethyl-1H-benzo[d]imidazole (CAS 20224-12-8)
- N-(p-Tolyl)-1,2,3,4-tetrahydronaphthalen-1-amine (CAS 192461-90-8)
- 1-(2-((2,4-Dichlorophenyl)amino)-4-methylthiazol-5-yl)ethan-1-one oxime (CAS 946387-05-9)
- Peptide Impurity 13 (CAS CATO-CPTD788813)
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