n-(4-Chlorobenzyl)-1-(thiophen-2-yl)methanamine CAS 774190-82-8
| CAS No. | 774190-82-8 |
| Molecular Formula | C12H12ClNS |
| Molecular Weight | 237.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of n-(4-Chlorobenzyl)-1-(thiophen-2-yl)methanamine (C12H12ClNS) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
n-(4-Chlorobenzyl)-1-(thiophen-2-yl)methanamine (CAS 774190-82-8), molecular formula C12H12ClNS and molecular weight 237.75 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12ClNS |
| Molecular Weight | 237.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related n Standards
- n-(4-Chlorobenzyl)-1-(thiophen-3-yl)methanamine (CAS 1038256-49-3)
- n-(2-Chlorobenzyl)-1-(thiophen-2-yl)methanamine (CAS 66200-70-2)
- 3-(4-Chlorobenzyl)-1-methylpiperidin-4-one (CAS 1510489-53-8)
- 6-((4-Chlorobenzyl)oxy)-2-azaspiro[3.3]heptane (CAS 1708160-24-0)
- 1-(1-(4-Chlorobenzyl)-1H-1,2,3-triazol-4-yl)ethan-1-ol (CAS 1443291-22-2)
- 1-(4-Chlorobenzyl)-5-oxopyrrolidine-3-carbaldehyde (CAS 1447962-33-5)
- 1-(3-Chlorobenzyl)piperidine-2,4-dione (CAS 845724-14-3)
- 1-(3-Chlorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1247438-10-3)
Recommended Standards
- octahydroisoquinoline-2(1H)-sulfonyl chloride (CAS 923130-51-2)
- 5-Chloro-2-methyl-N-(thiophen-2-ylmethyl)aniline (CAS 57280-85-0)
- quinoline-7-sulfonyl chloride (CAS 443692-93-1)
- 4-Chloro-N-((5-methylthiophen-2-yl)methyl)aniline (CAS 51306-04-8)
- Arachidyl Arachidate (CAS 22432-80-0)
- 2-(4-Isopropoxybenzoyl)-5-methylpyridine (CAS 1187166-78-4)
- s-(Cyanomethyl)-l-cysteine (CAS 175131-93-8)
- N-(2-Fluoro-6-nitrophenyl)piperidin-4-amine hydrochloride (CAS 1233954-80-7)
- 2-Amino-2-(4-chlorophenyl)ethan-1-ol (CAS 179811-64-4)
- 2-chloroprop-2-ene-1-sulfonyl chloride (CAS 40644-59-5)
- (S)-N-((S)-(5-(Diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl)(2-isopropylphenyl)methyl)-2-methylpropane-2-sulfinamide (CAS 2374225-96-2)
- N,N-dibenzyl-5-iodopyridin-2-amine (CAS 1408279-52-6)
- 5-Methoxy-4-methylpyridine-3-boronic acid (CAS 1451391-97-1)
- Cholecystokinin Octapeptide (sulfated) (H-2060.0005) (CAS 25679-23-6)
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