2-Phenylimidazole-4-carboxylic Acid CAS 77498-98-7
| CAS No. | 77498-98-7 |
| Molecular Formula | C10H8N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Phenylimidazole-4-carboxylic Acid (CAS 77498-98-7), molecular formula C10H8N2O2H2O and molecular weight 206.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Phenylimidazole-4-carboxylic Acid (C10H8N2O2H2O) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Phenylimidazole-4-carboxylic Acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8N2O2 H2O |
| Molecular Weight | 206.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 2 |
Related Phenylimidazole Standards
- 2-Phenylimidazole-4-carboxylic Acid Hydrate (CAS 1052410-02-2)
- 2-Phenylimidazole-4-carbonitrile (CAS 13317-73-2)
- 2-Methyl-4-phenylimidazole (CAS 13739-48-5)
- 1-Phenylimidazole-4-carboxylic Acid (CAS 18075-64-4)
- 670-95-1 4(5)-Phenylimidazole 1H-Imidazole, 4-phenyl- (9CI) Imidazole, 4-phenyl- (8CI) 4-Phenylimidazole EINECS 211-580-1 NSC 195337 (CAS 670-95-1)
- 5-Methyl-4-phenylimidazole (CAS 826-83-5)
- 4-Methyl-2-phenylimidazole (CAS 827-43-0)
Recommended Standards
- (2E)-1-[5-({[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}methyl)-4,5-dihydro-1,2-oxazol-3-yl]-3-{[4-(trifluoromethoxy)phenyl]amino}prop-2-en-1-one (CAS 344276-97-7)
- 3-Chloro-2-hydroxy-5-methoxybenzaldehyde (CAS 90110-33-1)
- (R,E)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-phenylhex-5-enoic acid (CAS 1272755-58-4)
- GDC-0994 (CAS 1453848-26-4)
- (R)-Pyrrolidine-2-carbonitrile 2,2,2-trifluoroacetate (CAS 1523530-11-1)
- 4-(4-Phenylpiperazin-1-yl)-6-(pyrrolidin-1-yl)pyrimidin-2-amine (CAS 339017-93-5)
- 3-Amino-6-methoxy-1H-indole-2-carbohydrazide (CAS 843621-55-6)
- N-(2-Benzylbenzo[d]oxazol-5-yl)-4-ethylbenzamide (CAS 785836-58-0)
- N,N-diethyl-1-(3-fluoroazetidin-3-yl)methanesulfonamide (CAS 2294414-68-7)
- Mast Cell Degranulating (MCD) Peptide HR-2 (CAS 80388-04-1)
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