1-chloro-2-fluoro-4-(methoxymethoxy)benzene CAS 775334-11-7
| CAS No. | 775334-11-7 |
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 1-chloro-2-fluoro-4-(methoxymethoxy)benzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
1-chloro-2-fluoro-4-(methoxymethoxy)benzene (CAS 775334-11-7) is a high-purity analytical reference standard with the molecular formula C8H8ClFO2 and a molecular weight of 190.60 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, 1-chloro-2-fluoro-4-(methoxymethoxy)benzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H8ClFO2 |
| Molecular Weight | 190.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
Related chloro Standards
- 3-Chloro-4-ethoxy-5-fluorophenol (CAS 1017778-82-3)
- 2-Chloro-4-ethyl-5-fluoro-6-methoxypyrimidine (CAS 1192479-51-8)
- (5-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1266177-72-3)
- 5-Chloro-3-fluoro-2-(2-hydroxyethylamino)pyridine (CAS 1280786-67-5)
- 4-Chloro-2-fluoro-3-methoxybenzyl alcohol (CAS 1323966-21-7)
- (R)-1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol, 97% (CAS 1453854-84-6)
- 1-(4-Chloro-3-fluorophenyl)ethane-1,2-diol (CAS 1558116-77-0)
- (3-Chloro-2-fluoro-4-methoxyphenyl)methanol (CAS 1616601-81-0)
Recommended Standards
- 1-(Difluoromethyl)cyclopropane-1-sulfonyl chloride (CAS 2091793-00-7)
- 2-(4-Chloro-2-fluorophenoxy)ethanol (CAS 6161-88-2)
- (4-Chloro-2-fluoro-5-methoxyphenyl)methanol (CAS 374780-15-1)
- 2-Chloro-1-fluoro-3-(methoxymethoxy)benzene (CAS 860296-13-5)
- 2-((1-Methylpyrrolidin-2-yl)methoxy)ethanamine (CAS 1353966-27-4)
- 2-(Methylamino)acetohydrazide (CAS 37115-47-2)
- N-(6-Chloro-4-morpholinopyrido[3,2-d]pyrimidin-2-yl)acetamide (CAS 897361-68-1)
- 4,5-dihydrofuran-2-carbonitrile (CAS 108734-03-8)
- 1-(3-Methylthiophen-2-yl)propan-1-ol (CAS 1250931-69-1)
- Ceftaroline Fosamil Impurity 1 (CAS 1277090-03-5)
- (R)-5-Fluoro-2-(pyrrolidin-2-yl)pyridine dihydrochloride (CAS 2241594-45-4)
- 2-(1-Methoxyethyl)-4-methylpyrimidine-5-carboxylic acid (CAS 1527616-91-6)
- 4-Chloro-N,N,2,6-tetramethylpyrimidin-5-amine (CAS 1823363-62-7)
- Tumor Targeted Pro-Apoptotic Peptide (CAS 1926163-30-5)
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