L-Proline monohydrochloride CAS 7776-34-3
| CAS No. | 7776-34-3 |
| Molecular Formula | C5H9NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
L-Proline monohydrochloride (CAS 7776-34-3), molecular formula C5H9NO2HCl and molecular weight 151.59 g/mol, is a CATO reference standard with documented purity and traceability.
L-Proline monohydrochloride (C5H9NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H9NO2 HCl |
| Molecular Weight | 151.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related L Standards
- L-Proline, 2-(2-pyridinylmethyl)-, hydrochloride (1:2) (CAS 1049732-38-8)
- L-Proline, 2-(3-pyridinylmethyl)-, hydrochloride (1:2) (CAS 1049732-88-8)
- L-Proline, 4-cyclohexyl-1-[2-[hydroxy(4-phenylbutyl)phosphinyl]acetyl]-, β-D-glucopyranuronosyl ester, (4S)- (CAS 113411-09-9)
- D-Proline, 2-(4-pyridinylmethyl)-, hydrochloride (1:2) (CAS 1217638-24-8)
- D-Proline, 2-(2-pyridinylmethyl)-, hydrochloride (1:2) (CAS 1217860-92-8)
- L-Proline-13C5, N-Boc (CAS 1313730-03-8)
- D-Proline-13C5,15N (CAS 1331908-17-8)
- L-Proline (CAS 147-85-3)
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- 2-(2-Chloro-5-nitrophenyl)pyridine hydrochloride (CAS 2254573-75-4)
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- 1-((((Tetrahydrofuran-2-yl)methyl)amino)methyl)cyclohexan-1-ol (CAS 1183011-89-3)
- 1-Benzhydryl-2-(difluoromethyl)azetidin-3-one (CAS 2231676-63-2)
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