Dotinurad Impurity 208 CAS 78083-73-5
| CAS No. | 78083-73-5 |
| Molecular Formula | C7H2Cl4O3 |
| Molecular Weight | 275.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dotinurad Impurity 208 (CAS 78083-73-5, C7H2Cl4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Dotinurad Impurity 208 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 275.90 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H2Cl4O3 |
| Molecular Weight | 275.90 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
Related Dotinurad Standards
- Dotinurad Impurity 126 (CAS CATO-C4X-2494126)
- Dotinurad Impurity 192 (CAS CATO-C4X-2494192)
- Dotinurad Impurity 254 (CAS CATO-C4X-2494254)
- Dotinurad Impurity 41 (CAS CATO-C4X-249441)
- Dotinurad Impurity 29 (CAS CATO-C4X-249429)
- Dotinurad Impurity 120 (CAS CATO-C4X-2494120)
- Dotinurad Impurity 121 (CAS CATO-C4X-2494121)
- Dotinurad Impurity 43 (CAS CATO-C4X-249443)
Recommended Standards
- 2,6-Dichloro-4-iodopyridine-3,5-d2 (CAS 2778147-42-3)
- 5-Bromo-1,3-dichloro-2-(difluoromethyl)benzene (CAS 1254034-21-3)
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- 2,3-Dibromobenzofuran (CAS 64150-61-4)
- Imatinib Impurity 46 (CAS 1170909-72-4)
- Mometasone Impurity 34 (CAS CATO-C4X-170434)
- Lasmiditan Impurity 39 (CAS 1347604-52-7)
- 1-(Tetrahydro-2H-pyran-4-yl)piperazin-2-one (CAS 1147422-83-0)
- n,n-Diethyl-2-methylpyrimidine-4-carboxamide (CAS 1280816-18-3)
- 6,8-Dichlorochroman-3-carboxylic acid (CAS 885271-47-6)
- 2-Cyclopropoxy-3-methylbenzoic acid (CAS 1243364-42-2)
- Azelastine impurity 63 (CAS CATO-C4X-139663)
- 6-Amino-2-fluoro-3,4-dinitrotoluene (CAS 1082041-94-8)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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