Dotinurad Impurity 121 CAS CATO-C4X-2494121
| CAS No. | CATO-C4X-2494121 |
| Molecular Formula | C8H4Cl4O2 |
| Molecular Weight | 273.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Dotinurad Impurity 121 (CAS CATO-C4X-2494121), a pharmacopoeial impurity reference standard (molecular formula C8H4Cl4O2, MW 273.93 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dotinurad Impurity 121 (C8H4Cl4O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C8H4Cl4O2 |
| Molecular Weight | 273.93 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Dotinurad Standards
- Dotinurad Impurity 120 (CAS CATO-C4X-2494120)
- Dotinurad Impurity 29 (CAS CATO-C4X-249429)
- Dotinurad Impurity 208 (CAS 78083-73-5)
- Dotinurad Impurity 126 (CAS CATO-C4X-2494126)
- Dotinurad Impurity 192 (CAS CATO-C4X-2494192)
- Dotinurad Impurity 254 (CAS CATO-C4X-2494254)
- Dotinurad Impurity 41 (CAS CATO-C4X-249441)
- Dotinurad Impurity 43 (CAS CATO-C4X-249443)
Recommended Standards
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- Rivaroxaban Impurity N19 (CAS 241483-00-1)
- Landiolol Impurity 142 (CAS CATO-C4X-2621142)
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- 2-(2-Chloroacetamido)benzyl 2-chloroacetate (CAS 1313712-59-2)
- Methyl (3R,4S,5S)-4-((tert-butoxycarbonyl)amino)-3-hydroxy-5-methylheptanoate (CAS 141394-85-6)
- 2-(2-Cyanophenyl)-4-trifluoromethylacetophenone (CAS 898784-49-1)
- cis-2-(3,5-difluorophenoxy)cyclopentan-1-amine hydrochloride (CAS 1808707-05-2)
- Semaglutide impurity 99 (CAS CATO-C4X-222699)
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