4-(4-(Trifluoromethyl)phenoxy)benzoic acid CAS 78161-82-7
| CAS No. | 78161-82-7 |
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(4-(Trifluoromethyl)phenoxy)benzoic acid (CAS 78161-82-7) is a high-purity analytical reference standard with the molecular formula C14H9F3O3 and a molecular weight of 282.21 g/mol.
Based on its molecular formula C14H9F3O3, 4-(4-(Trifluoromethyl)phenoxy)benzoic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 282.21 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 3-[3-(trifluoromethyl)phenoxy]benzoic acid (CAS 127389-09-7)
- (E)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylic acid (CAS 62806-37-5)
- 2-(3-(Trifluoromethyl)phenoxy)benzoic acid (CAS 6641-59-4)
- 2-(4-(Trifluoromethyl)phenoxy)benzoicacid (CAS 402714-65-2)
- 3-[4-(Trifluoromethyl)phenoxy]benzoic Acid (CAS 72178-29-1)
- 4-[3-(Trifluoromethyl)phenoxy]benzoic acid (CAS 632366-11-1)
- 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzamide (CAS 1024143-17-6)
- 4-Methyl-2-[4-(trifluoromethyl)phenyl]pyrimidine-5-carboxylic acid (CAS 1119449-88-5)
Recommended Standards
- 3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (3-cyclobutylthiophen-2-yl)boronate (CAS 2223040-29-5)
- 4-(4-Trifluoromethoxyphenyl)benzoic acid (CAS 728919-11-7)
- 4'-(Trifluoromethoxy)-[1,1'-biphenyl]-2-carboxylic acid (CAS 408366-18-7)
- 3-((2-Hydroxy-4-nitrophenyl)amino)pyrazine-2,5-dicarbonitrile (CAS 918410-46-5)
- 4-Chlorobenzenesulfonohydrazide (CAS 2751-25-9)
- (1S)-1-(5-Chloropyridin-2-yl)ethan-1-amine dihydrochloride (CAS 1807941-73-6)
- 1-(2-Nitro-5-thiomorpholinophenyl)ethan-1-one (CAS 923248-96-8)
- 2-(4-(4-(Methylamino)phenyl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-ol (CAS 1609195-15-4)
- 3-Amino-3-(3-iodophenyl)propanoic acid (CAS 299169-95-2)
- 3-Bromo-N-(4-methylthiazol-2-yl)benzamide (CAS 377066-38-1)
- 4-(2,2-Dimethylthiomorpholino)butan-2-one (CAS 1600592-31-1)
- (5-Carbamoyl-2-chlorophenyl)boronic acid (CAS 1150114-35-4)
- 5-Bromoisothiazol-3-amine (CAS 2387239-22-5)
- Prolactin-Releasing Peptide (12-31) (human) (CAS 235433-36-0)
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