4-[3-(Trifluoromethyl)phenoxy]benzoic acid CAS 632366-11-1
| CAS No. | 632366-11-1 |
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[3-(Trifluoromethyl)phenoxy]benzoic acid.
4-[3-(Trifluoromethyl)phenoxy]benzoic acid (CAS 632366-11-1) is a high-purity analytical reference standard with the molecular formula C14H9F3O3 and a molecular weight of 282.21 g/mol.
4-[3-(Trifluoromethyl)phenoxy]benzoic acid (C14H9F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-[3-(Trifluoromethyl)phenoxy]benzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9F3O3 |
| Molecular Weight | 282.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1985 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 3-[3-(trifluoromethyl)phenoxy]benzoic acid (CAS 127389-09-7)
- (E)-3-(5-(3-(trifluoromethyl)phenyl)furan-2-yl)acrylic acid (CAS 62806-37-5)
- 2-(3-(Trifluoromethyl)phenoxy)benzoic acid (CAS 6641-59-4)
- 2-(4-(Trifluoromethyl)phenoxy)benzoicacid (CAS 402714-65-2)
- 3-[4-(Trifluoromethyl)phenoxy]benzoic Acid (CAS 72178-29-1)
- 4-(4-(Trifluoromethyl)phenoxy)benzoic acid (CAS 78161-82-7)
- 4-((5-(Trifluoromethyl)pyridin-2-yl)oxy)benzamide (CAS 1024143-17-6)
- 4-Methyl-2-[4-(trifluoromethyl)phenyl]pyrimidine-5-carboxylic acid (CAS 1119449-88-5)
Recommended Standards
- 4-[2-(Trifluoromethoxy)phenyl]benzoic acid (CAS 926220-09-9)
- 4-Hydroxy-2'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 400744-89-0)
- 4'-(Trifluoromethoxy)biphenyl-3-carboxylic acid (CAS 728919-12-8)
- 4-Hydroxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid (CAS 43029-72-7)
- 3-Ethoxy-6-methyl-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one (CAS 146824-77-3)
- α-D-Glucopyranose, 2-(acetylamino)-2,4-dideoxy-4-fluoro-, 1,3,6-triacetate (CAS 129785-44-0)
- bicyclo[4.1.0]heptan-3-amine hydrochloride (CAS 78293-49-9)
- [1,2,4]Triazolo[1,5-a]pyrimidin-2-yl(1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)methanone (CAS 1214413-92-9)
- Dopamine Impurity 112 (CAS CATO-C4X-1908112)
- (S)-2,2-dimethyl-1-(3-(trifluoromethoxy)phenyl)propan-1-amine (CAS 1389368-02-8)
- 2-Methyl-1,2-di-4-pyridinyl-1-propanone (CAS 17286-92-9)
- 1-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carbohydrazide (CAS 1987070-55-2)
- 2-Fluoro-4-methylbenzene-1-thiol (CAS 956037-84-6)
- Semaglutide impurity 257 (CAS CATO-C4X-2226257)
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