Nepafenac Impurity 5 CAS 78281-71-7
| CAS No. | 78281-71-7 |
| Molecular Formula | C15H13ClN2O2 |
| Molecular Weight | 288.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies Nepafenac Impurity 5 (CAS 78281-71-7), a certified reference material (molecular formula C15H13ClN2O2, MW 288.73 g/mol) for analytical method development and quality control.
Nepafenac Impurity 5 (C15H13ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H13ClN2O2 |
| Molecular Weight | 288.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nepafenac Standards
Recommended Standards
- N'-Benzylidene-2-(4-chlorophenoxy)acetohydrazide (CAS 2503-75-5)
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- N1-benzyl-N2-(3-chlorophenyl)oxalamide (CAS 329079-27-8)
- 2-amino-N-(2-chlorophenyl)-2-(phenylhydrazinylidene)acetamide 2-azanyl-N-(2-chlorophenyl)-2-(phenylhydrazinylidene)ethanamide 475162-11-9 A827261 (CAS 475162-11-9)
- 4-((4-Methylbenzyl)amino)benzoic acid (CAS 64518-48-5)
- 3-((Hexyloxy)methyl)benzenethiol (CAS 1443351-01-6)
- Amino(1,3,5-trimethyl-1H-pyrazol-4-yl)acetic acid (CAS 1025555-34-3)
- 1-{4-[(4-Chlorophenyl)thio]-3-fluorophenyl}ethanone (CAS 1030429-38-9)
- 2-Phenyl-4-[(phenylsulfanyl)methyl]-6-(pyrrolidin-1-yl)pyrimidine (CAS 303147-73-1)
- 4-Amino-6-phenylpyridazin-3(2H)-one (CAS 89868-06-4)
- 4,6-Dichloro-2,5-diphenylpyrimidine (CAS 29133-99-1)
- Methyl 2-amino-5-chloro-4-nitrobenzoate (CAS 530084-00-5)
- 2,2-Bis(4-isocyanatophenyl)hexafluoropropane (CAS 10224-18-7)
- Acetyl Dipeptide-1 (CAS 196604-48-5)
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