3'-Phenyl-2-(trifluoromethyl)-4'H-spiro[chromene-4,5'-isoxazole] CAS 784144-78-1
| CAS No. | 784144-78-1 |
| Molecular Formula | C18H12F3NO2 |
| Molecular Weight | 331.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3'-Phenyl-2-(trifluoromethyl)-4'H-spiro[chromene-4,5'-isoxazole].
3'-Phenyl-2-(trifluoromethyl)-4'H-spiro[chromene-4,5'-isoxazole] (CAS 784144-78-1), molecular formula C18H12F3NO2 and molecular weight 331.29 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3'-Phenyl-2-(trifluoromethyl)-4'H-spiro[chromene-4,5'-isoxazole] (C18H12F3NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 331.29 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 3'-Phenyl-2-(trifluoromethyl)-4'H-spiro[chromene-4,5'-isoxazole] under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H12F3NO2 |
| Molecular Weight | 331.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Phenyl Standards
- 3-METHYL-2-(3-(TRIFLUOROMETHYL)PHENYL)QUINOLINE-4-CARBOXYLIC ACID (CAS 1533-17-1)
- 2,2'-(4-(Trifluoromethyl)pyridine-2,6-diyl)diphenol (CAS 603131-01-7)
- 3-Phenyl-4-({[3-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 338975-63-6)
- 3-Phenyl-4-({[4-(trifluoromethyl)phenyl]amino}methylidene)-4,5-dihydro-1H-pyrazol-5-one (CAS 477851-10-8)
- n-(5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide (CAS 865660-10-2)
- methyl 4-(2-(4-(trifluoromethyl)piperidin-1-yl)ethoxy)benzoate (CAS 1000339-87-6)
- 5-((3-(Trifluoromethyl)phenyl)amino)-1,6-dihydro-[1,1'-biphenyl]-3(2H)-one (CAS 1020252-08-7)
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Recommended Standards
- 2-(((Benzyloxy)carbonyl)amino)-2-(trifluoromethyl)hex-5-enoic acid (CAS 887267-90-5)
- (Z)-{1-[3-(morpholin-4-yl)-5-(trifluoromethyl)pyridin-2-yl]ethylidene}amino acetate (CAS 860650-99-3)
- 4-Bromo-4'-heptyl-1,1'-biphenyl (CAS 58573-93-6)
- (4Z)-1-Phenyl-4-[(phenylamino)methylidene]-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-one (CAS 477851-28-8)
- 3-[(1r,3as,3bs,6r,6ar,7as,9ar)-6-(3-hydroxy-1-propen-2-yl)-3a,9a- Dimethyl-1-[(2r)-6-methyl-5-hepten-2-yl]decahydro-1h-cyclopenta[a ]cyclopropa[e]naphthalen-6a(7h)-yl]propanoic Acid 925932-08-7 (CAS 925932-08-7)
- 4-(Difluoromethyl)-3-fluoro-6-hydroxypicolinoyl chloride (CAS 1806924-28-6)
- 2-chloro-N-[4-(4-methylpiperidin-1-yl)phenyl]acetamide hydrochloride (CAS 1052089-51-6)
- Brd 4354 (CAS 315698-07-8)
- N-[3-(2,2-Diethoxyethoxy)benzyl]-2,2-diethoxyethylamine (CAS 2006277-32-1)
- 2-(Allylthio)-5,6,7,8-tetrahydroquinoline-3-carbonitrile (CAS 112629-71-7)
- (2E)-1-(3-Methoxyphenyl)-3-(3-methylthiophen-2-yl)prop-2-en-1-one (CAS 358656-72-1)
- Paraben Impurity 3 (CAS CATO-C4X-25693)
- Varenicline Impurity 34 (CAS CATO-C4X-196234)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
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