2-Chloro-5-(chloromethyl)-4-(trifluoromethyl)thiazole CAS 78450-98-3
| CAS No. | 78450-98-3 |
| Molecular Formula | C5H2Cl2F3NS |
| Molecular Weight | 236.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-(chloromethyl)-4-(trifluoromethyl)thiazole (CAS 78450-98-3), molecular formula C5H2Cl2F3NS and molecular weight 236.04 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-5-(chloromethyl)-4-(trifluoromethyl)thiazole (C5H2Cl2F3NS) contains a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 236.04 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-5-(chloromethyl)-4-(trifluoromethyl)thiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H2Cl2F3NS |
| Molecular Weight | 236.04 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-chloro-3-(chloromethyl)-5-(trifluoromethyl)pyridine (CAS 1026086-96-3)
- 2-Chloro-n-(5-chloro-2-fluorophenyl)propanamide (CAS 1098361-04-6)
- 3-Chloro-N-(3-chloro-4-fluorophenyl)propanamide (CAS 131605-66-8)
- 2-Chloro-N-(2-chloro-4-fluorophenyl)propanamide (CAS 571153-08-7)
- 2-Chloro-N-(2-chloro-6-fluorobenzyl)acetamide (CAS 680579-73-1)
- 2-Chloro-N-(3-chloro-4-fluorophenyl)propanamide (CAS 868771-19-1)
- 2-Chloro-n-(4-chloro-2-fluorophenyl)propanamide (CAS 949204-45-9)
- 3-Chloro-N-(4-chloro-2-fluorophenyl)propanamide (CAS 545385-13-5)
Recommended Standards
- 5-Bromo-2-nitrothiophene-3-carbaldehyde (CAS 1093878-18-2)
- 4,4,5,5-Tetramethyl-2-((1S,2S)-2-(trifluoromethyl)cyclopropyl)-1,3,2-dioxaborolane (CAS 2766566-71-4)
- 5-Fluoro-2-iodotoluene (CAS 66256-28-8)
- 4-Bromo-2-fluoro-3-(methoxymethoxy)pyridine (CAS 2586126-66-9)
- 4-(3-Fluorophenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile (CAS 1713477-68-9)
- 3-Methyl-3,8-diazabicyclo[4.2.0]octane2,2,2-trifluoroacetate (CAS 2173083-55-9)
- 3-Fluoroisonicotinaldehyde hydrofluoride (CAS 1820741-48-7)
- 1-(6-Nitropyridin-3-yl)piperazine hydrochloride (CAS 1221726-34-6)
- 2-(1,3-dithiolan-2-ylidene)malononitrile (CAS 2276-43-9)
- 4,4-Dimethyl-2-(1,10-phenanthrolin-2-yl)-4,5-dihydrooxazole (CAS 1101906-42-6)
- 2,2,3-Trimethylcyclopent-3-ene-1-carboxaldehyde (CAS 33843-21-9)
- (6-Amino-8-bromoimidazo[1,2-a]pyridin-2-yl)methanol (CAS 1780454-34-3)
- 1-(9-Benzyl-3,9-diazabicyclo[4.2.1]Nonan-3-yl)ethan-1-one (CAS 387870-06-6)
- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
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