Sucralose EP Impurity H CAS 78508-21-1
| CAS No. | 78508-21-1 |
| Molecular Formula | C6H10Cl2O4 |
| Molecular Weight | 217.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sucralose EP Impurity H.
Sucralose EP Impurity H (CAS 78508-21-1), molecular formula C6H10Cl2O4 and molecular weight 217.05 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Sucralose EP Impurity H (C6H10Cl2O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H10Cl2O4 |
| Molecular Weight | 217.05 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
Related Sucralose Standards
- Sucralose EP Impurity H (Mixture of Isomers) (CAS 2366151-13-3)
- Sucralose EP Impurity I (CAS 848642-13-7)
- Sucralose Impurity 2 (CAS 475491-24-8)
- Sucralose Impurity 4 (CAS CATO-C4X-28294)
- Sucralose EP Impurity F (CAS 61854-83-9)
- Sucralose EP Impurity G (CAS 105066-20-4)
- Sucralose EP Impurity E (CAS 55832-24-1)
- Sucralose EP Impurity B (CAS 40631-75-2)
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