5,6-Difluorobenzimidazole CAS 78581-99-4
| CAS No. | 78581-99-4 |
| Molecular Formula | C7H4F2N2 |
| Molecular Weight | 154.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5,6-Difluorobenzimidazole (CAS 78581-99-4) is a high-purity analytical reference standard with the molecular formula C7H4F2N2 and a molecular weight of 154.12 g/mol.
The molecular framework of 5,6-Difluorobenzimidazole (C7H4F2N2) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5,6-Difluorobenzimidazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H4F2N2 |
| Molecular Weight | 154.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluorobenzimidazole Standards
Recommended Standards
- 5,6-Difluoro-1H-indazole (CAS 944898-96-8)
- 5,6-Dihydroisoxazolo[5,4-c]pyridine-3,7(2H,4H)-dione (CAS 91305-43-0)
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- 5,7-Dihydrofuro[3,4-d]pyrimidine-2,4-diol (CAS 848398-40-3)
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