5-Chloro-1,3-dimethyl-6-nitroquinazoline-2,4(1H,3H)-dione CAS 78754-85-5
| CAS No. | 78754-85-5 |
| Molecular Formula | C10H8ClN3O4 |
| Molecular Weight | 269.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-1,3-dimethyl-6-nitroquinazoline-2,4(1H,3H)-dione.
CATO supplies 5-Chloro-1,3-dimethyl-6-nitroquinazoline-2,4(1H,3H)-dione (CAS 78754-85-5), a certified reference material (molecular formula C10H8ClN3O4, MW 269.64 g/mol) for analytical method development and quality control.
The molecular framework of 5-Chloro-1,3-dimethyl-6-nitroquinazoline-2,4(1H,3H)-dione (C10H8ClN3O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Chloro-1,3-dimethyl-6-nitroquinazoline-2,4(1H,3H)-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3O4 |
| Molecular Weight | 269.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 3-[(4-chloro-3-nitrophenyl)methyl]imidazolidine-2,4-dione (CAS 1097788-31-2)
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- 3-(4-Chloro-3-nitrophenyl)-5-(methoxymethyl)-1,2,4-oxadiazole (CAS 879761-45-2)
- Ethyl 2-chloro-3-cyano-6-methyl-5-nitroisonicotinate (CAS 72701-63-4)
- Ethyl 5-chloro-4-nitrobenzofuran-2-carboxylate (CAS 412336-55-1)
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Recommended Standards
- 5-(Chloromethyl)-3-((4-nitrophenoxy)methyl)-1,2,4-oxadiazole (CAS 306936-72-1)
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- 3-acetamido-2,4-difluorobenzene-1-sulfonyl chloride (CAS 1803600-07-8)
- 3-[(3-Carboxyacryloyl)amino]-4-chlorobenzoic acid (CAS 1049157-75-6)
- 4-(Difluoromethyl)-5-iodo-6-(trifluoromethoxy)picolinic acid (CAS 1806180-55-1)
- N6,N6-Dimethyl-1H-indazole-5,6-diamine (CAS 1499162-43-4)
- 3-(5-Hydroxy-2-nitrophenyl)-2-oxopropanoic acid (CAS 412284-26-5)
- FA-Ala-OSu (M-1345.0001) (CAS 76079-01-1)
- 2-Methyl-4-(4-methylpiperazin-1-yl)-6-(piperazin-1-yl)pyrimidine (CAS 1706457-43-3)
- 2-(2-Bromo-5-methylphenyl)propan-2-ol (CAS 1393477-32-1)
- (E)-Dodec-8-en-1-ol (CAS 42513-42-8)
- 7-Amino-2-methyl-3-phenylpyrazolo[1,5-a]pyrimidine-6-carbonitrile (CAS 387361-34-4)
- Diethyl (3-Diethylaminopropyl)-Malonate (CAS 32941-05-2)
- Insulin Degludec impurity 4 (CAS CATO-C4X-21574)
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