Doxycycline EP Impurity E CAS 79-57-2
| CAS No. | 79-57-2 |
| Molecular Formula | C22H24N2O9 |
| Molecular Weight | 460.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Doxycycline EP Impurity E (CAS 79-57-2, C22H24N2O9) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Doxycycline EP Impurity E (C22H24N2O9) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 460.43 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Doxycycline EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O9 |
| Molecular Weight | 460.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >85% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Doxycycline Standards
- Doxycycline Impurity 26 (CAS CATO-C4X-193126)
- Doxycycline Impurity 19 (CAS CATO-C4X-193119)
- Doxycycline Impurity 25 (CAS CATO-C4X-193125)
- Doxycycline-13CD3 (CAS 1902958-13-7)
- Doxycycline-13C-d3 (CAS CATO-C4X-193111)
- Doxycycline-d3 (CAS 2747918-45-0)
- Doxycycline-d3 (CAS CATO-C4X-193110)
- Doxycycline EP Impurity A (CAS 3219-99-6)
Recommended Standards
- Sodium Cromoglicate Impurity 14 (CAS CATO-C4X-201114)
- Gemcitabine Impurity 35 (CAS CATO-C4X-137235)
- Sodium Cromoglicate Impurity 19 (CAS CATO-C4X-201119)
- Apiopaeonoside (CAS 100291-86-9)
- Mosapride Impurity 47 (CAS CATO-C4X-104447)
- Benzydamine Hydrochloride EP Impurity A (CAS 87453-76-7)
- Pregabalin Impurity 23 (CAS 181289-34-9)
- (1-(Tert-butoxycarbonyl)-1,2,5,6-tetrahydropyridin-3-yl)trifluoroborate (CAS 2416056-25-0)
- [6-(2,4-Dimethoxyphenyl)-2-pyridyl]methanol (CAS 887981-31-9)
- Methyl 4-{[2-(4-chlorobenzamido)-4-(trifluoromethyl)phenyl]amino}butanoate (CAS 339101-69-8)
- 2-(Phenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid (CAS 1956369-45-1)
- Zolazepam (CAS 31352-82-6)
- (S)-1-(benzylamino)-3-(benzyloxy)propan-2-ol (CAS 205242-64-4)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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