Doxycycline EP Impurity A CAS 3219-99-6
| CAS No. | 3219-99-6 |
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | 444.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Doxycycline EP Impurity A (CAS 3219-99-6) is a certified pharmaceutical impurity reference standard with the molecular formula C22H24N2O8 and a molecular weight of 444.43 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Doxycycline EP Impurity A is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 444.43 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Doxycycline EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | 444.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Doxycycline Standards
- Doxycycline EP Impurity C (CAS 6543-77-7)
- Doxycycline EP Impurity D (CAS 97583-08-9)
- Doxycycline Impurity 8 (CAS CATO-C4X-19318)
- Doxycycline (CAS 564-25-0)
- Doxycycline Impurity 21 (CAS CATO-C4X-193121)
- Doxycycline EP Impurity F (CAS 122861-53-4)
- Doxycycline EP Impurity B (CAS CATO-C4X-19312)
- Doxycycline-d3 (CAS 2747918-45-0)
Recommended Standards
- Thalidomide-O-PEG3-propargyl (CAS 2098799-76-7)
- N-(3-cyano-4-((3-(trifluoromethyl)phenyl)sulfinyl)phenyl)-3-methoxybenzamide (CAS 477710-04-6)
- Methyl 4-O-[4-6-O-benzylidene)-β-D-galactopyranosyl] β-D-glucopyranoside (CAS 56865-31-7)
- Methyl 4-6-O-benzylidene-3-O-(b-D-glucopyranoside)-α-D-glucopyranoside (CAS 72656-05-4)
- Bisoprolol Impurity 72 (CAS 2999705-55-2)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
- Propofol EP Impurity H (CAS 99-89-8)
- 2-(2-(4-(Tert-butyl)phenyl)-5-methyloxazol-4-yl)acetic acid (CAS 1017181-51-9)
- Methyl 4-(oxazol-2-yl)benzoate (CAS 421553-40-4)
- Levodopa Impurity 12 (CAS 25520-73-4)
- 5-Oxo-N-(pyridin-2-ylmethyl)-1,4-thiazepane-3-carboxamide (CAS 1396631-59-6)
- 3,4-Di-O-acetyl-6-deoxy-L-glucal (CAS 34819-86-8)
- 1-(3-Chlorophenyl)pyrrolidin-3-yl carbamate (CAS 6317-54-0)
- Pancreatic Polypeptide (1-17)-(Ala31,Aib32)-Neuropeptide Y (18-36) (human) trifluoroacetate salt (CAS 313988-70-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com