Methotrexate Impurity 43 CAS 79974-20-2
| CAS No. | 79974-20-2 |
| Molecular Formula | C14H18N2O5 |
| Molecular Weight | 294.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Methotrexate Impurity 43 (CAS 79974-20-2), a pharmacopoeial impurity reference standard (molecular formula C14H18N2O5, MW 294.30 g/mol) used for the identification and quantification of trace impurities in APIs.
Methotrexate Impurity 43 (C14H18N2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Methotrexate Impurity 43 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H18N2O5 |
| Molecular Weight | 294.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 2 |
Related Methotrexate Standards
- Methotrexate Impurity 42 (CAS 79974-19-9)
- Methotrexate Impurity 44 (CAS 93528-16-6)
- Methotrexate Impurity 66 (CAS CATO-C4X-115466)
- Methotrexate Impurity 68 (CAS CATO-C4X-115468)
- Methotrexate Impurity 70 (CAS CATO-C4X-115470)
- Methotrexate Impurity 77 (CAS CATO-C4X-115477)
- Methotrexate Impurity 34 (CAS CATO-C4X-115434)
- Methotrexate Impurity 40 (CAS 94807-78-0)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com