6-Chloropyridine-2-carbonyl chloride CAS 80099-98-5
| CAS No. | 80099-98-5 |
| Molecular Formula | C6H3Cl2NO |
| Molecular Weight | 176.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Chloropyridine-2-carbonyl chloride.
6-Chloropyridine-2-carbonyl chloride (CAS 80099-98-5), molecular formula C6H3Cl2NO and molecular weight 176.00 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 6-Chloropyridine-2-carbonyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 176.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Chloropyridine-2-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molecular Weight | 176.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloropyridine Standards
- 3-Chloropyridine-2-carbonyl chloride (CAS 128073-02-9)
- 2-Chloropyridine-4-carbonyl chloride 65287-34-5 cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine (CAS 65287-34-5)
- 6-Chloropyridine-3-sulfinic acid (CAS 99903-02-3)
- 2-Chloropyridine 1-oxide hydrochloride (CAS 20295-64-1)
- (4-Chloropyridine-2,6-diyl)dimethanol (CAS 1817-20-5)
- 2-Chloropyridine-3-carbothioamide (CAS 1240596-59-1)
- 6-Chloropyridine-2-carbothioamide (CAS 16225-59-5)
- 2-Chloropyridine-4-carbothioamide (CAS 91447-89-1)
Recommended Standards
- 6-Chloronicotinoyl Chloride (CAS 58757-38-3)
- 5-Chloronicotinoyl chloride (CAS 85320-79-2)
- Methylenediphosphonic Acid (CAS 1984-15-2)
- 5,6-Dichloropyridyl-3-carboxaldehyde (CAS 71690-05-6)
- Tert-butyl (6-ethynylspiro[3.3]Heptan-2-yl)carbamate (CAS 1809337-32-3)
- 2,2-Bis(bromomethyl)-1,3-dioxolane (CAS 20599-01-3)
- Propanoic acid, 2-[(3,5-dichlorophenyl)hydrazono]-, ethyl ester (CAS 103855-01-2)
- XD14 (CAS 1370888-71-3)
- 2-(4-Methylpiperidin-1-yl)-2-phenylethan-1-amine (CAS 889939-97-3)
- Methyl 1-methyl-2-oxo-1,2-dihydropyrimidine-5-carboxylate (CAS 50628-35-8)
- tert-Butyl 3-(((6-ethoxypyrimidin-4-yl)oxy)methyl)piperidine-1-carboxylate (CAS 1353954-07-0)
- n-(Sec-butyl)-4-nitroaniline (CAS 4138-37-8)
- Isoquinolin-1-ylmethanamine hydrochloride (CAS 1177303-46-6)
- D-[Ser]8-Semaglutide (CAS CATO-C4X-2226207)
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