2-Chloro-5-(2,4-difluorobenzoyl)pyridine CAS 80099-96-3
| CAS No. | 80099-96-3 |
| Molecular Formula | C12H6ClF2NO |
| Molecular Weight | 253.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-(2,4-difluorobenzoyl)pyridine (C12H6ClF2NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2-Chloro-5-(2,4-difluorobenzoyl)pyridine (CAS 80099-96-3) is a high-purity analytical reference standard with the molecular formula C12H6ClF2NO and a molecular weight of 253.63 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H6ClF2NO |
| Molecular Weight | 253.63 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-(2,5-difluorobenzoyl)pyridine (CAS 1187165-19-0)
- 2-Chloro-5-(3,5-difluorobenzoyl)pyridine (CAS 1187169-72-7)
- 2-chloro-5-(trifluoromethoxy)benzo[d]thiazole (CAS 1206541-62-9)
- 2-Chloro-6-(trifluoromethoxy)benzothiazole (CAS 133840-96-7)
- 2-Chloro-1-isocyanato-4-trifluoromethylsulfanyl-benzene (CAS 55225-89-3)
- 2-Chloro-4-isocyanato-1-[(trifluoromethyl)-thio]benzene (CAS 76729-41-4)
- 2-Chloro-5-(2,3-difluorobenzoyl)pyridine (CAS 251366-35-5)
- 5-chloro-2-methylsulfanyl-6-(trifluoromethyl)pyrimidine-4-carbonitrile (CAS 2843613-94-3)
Recommended Standards
- 8-Chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-thiol (CAS 571917-27-6)
- Methyl 1-(2-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate (CAS 1000576-85-1)
- (6-Chloropyridin-3-yl)(2,6-difluorophenyl)methanone (CAS 490038-59-0)
- 8-Chloro-4-hydroxy-7-methoxyquinoline-2-carboxylic acid (CAS 1001095-54-0)
- (3Z)-4-[(3,5-Dimethoxyphenyl)amino]-3-phenylbut-3-en-2-one (CAS 1164552-51-5)
- Glycerone phosphate (CAS 57-04-5)
- (1-Acetyl-2,2,6,6-tetramethylpiperidin-4-ylidene)amino 4-fluorobenzoate (CAS 478079-93-5)
- 3-((4-Bromo-3,5-dimethylphenoxy)methyl)cyclobutan-1-one (CAS 1544740-14-8)
- 1-(Bromomethyl)-2,4-difluoro-5-methylbenzene (CAS 315204-37-6)
- (R)-4-(1-amino-2,2,2-trifluoroethyl)phenol (CAS 1187928-59-1)
- 1-(tert-Butyl)-3-iodo-5-methylbenzene (CAS 111220-30-5)
- 2-Hydroxy-5-(trifluoromethyl)phenylboronic Acid Pinacol Ester (CAS 779331-13-4)
- Ethyl 2-cyano-4-ethoxybut-2-enoate (CAS 64046-50-0)
- C-Peptide (human) (CAS 33017-11-7)
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