Methyl 2-(4-chlorophenyl)quinoline-4-carboxylate CAS 80221-37-0
| CAS No. | 80221-37-0 |
| Molecular Formula | C17H12ClNO2 |
| Molecular Weight | 297.74 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 2-(4-chlorophenyl)quinoline-4-carboxylate.
Methyl 2-(4-chlorophenyl)quinoline-4-carboxylate (CAS 80221-37-0) is a high-purity analytical reference standard with the molecular formula C17H12ClNO2 and a molecular weight of 297.74 g/mol.
The molecular framework of Methyl 2-(4-chlorophenyl)quinoline-4-carboxylate (C17H12ClNO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H12ClNO2 |
| Molecular Weight | 297.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- 2-(2-Chlorophenyl)-8-methylquinoline-4-carboxylic acid (CAS 107027-38-3)
- 2-(4-Chlorophenyl)-8-methylquinoline-4-carboxylic acid (CAS 107027-43-0)
- 2-(3-(3-Chlorophenyl)-2-oxoimidazolidin-1-yl)-N-(2-hydroxyethyl)acetamide (CAS 1251699-20-3)
- N-(5-(4-Chlorophenyl)-1H-pyrazol-3-yl)benzamide (CAS 13097-20-6)
- N-(2-(2-Chlorophenyl)-2-methoxyethyl)-2-oxoimidazolidine-1-carboxamide (CAS 1795478-07-7)
- (Z)-4-(1-(4-Chlorophenyl)ethylidene)-2-phenyloxazol-5(4H)-one (CAS 69015-81-2)
- 1-(2-Chlorophenyl)-7-methylisoquinoline-3-carboxylic acid (CAS 89242-28-4)
- 1-(4-Chlorophenyl)-2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-one (CAS 60420-43-1)
Recommended Standards
- Methyl 1-chloro-4-phenylisoquinoline-3-carboxylate (CAS 78945-98-9)
- Methyl 2-chloro-4-phenylquinoline-3-carboxylate (CAS 94502-05-3)
- Methyl 1-(2-chlorophenyl)isoquinoline-3-carboxylate (CAS 439614-63-8)
- N-(2-Chlorophenyl)-3-hydroxy-2-naphthalenecarboxamide (CAS 6704-40-1)
- (S)-3-amino-3-(5-fluoro-2-methylphenyl)propanoic acid hcl (CAS 1213402-08-4)
- 1-Amino-4-(furan-2-yl)-2-imino-1,2-dihydropyridine-3-carbonitrile (CAS 108766-99-0)
- (E)-(4-Styrylphenyl)methanamine (CAS 36092-33-8)
- 5-Fluoro-6-iodo-1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (CAS 1261365-98-3)
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