3-(4-Chlorophenyl)-3-(4-fluorophenyl)propanoic acid CAS 80272-10-2
| CAS No. | 80272-10-2 |
| Molecular Formula | C15H12ClFO2 |
| Molecular Weight | 278.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(4-Chlorophenyl)-3-(4-fluorophenyl)propanoic acid (CAS 80272-10-2), molecular formula C15H12ClFO2 and molecular weight 278.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(4-Chlorophenyl)-3-(4-fluorophenyl)propanoic acid (C15H12ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(4-Chlorophenyl)-3-(4-fluorophenyl)propanoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H12ClFO2 |
| Molecular Weight | 278.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
Related Chlorophenyl Standards
- 3-(3-Chlorophenyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 1255784-16-7)
- 2-[3-(4-Chlorophenyl)-5-Fluorophenyl]Propanoic Acid (CAS 75852-61-8)
- 3-(4-Chlorophenyl)thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (CAS 852854-16-1)
- 6-(2-Chlorophenyl)imidazo[2,1-b]thiazole-3-carboxylic acid (CAS 912770-05-9)
- 6-(3-Chlorophenyl)imidazo[2,1-b]thiazole-3-carboxylic acid (CAS 912770-22-0)
- 7-(2-chlorophenyl)-5-hydroxy-2H-1,3-benzoxathiol-2-one (CAS 301681-73-2)
- 7-(4-Chlorophenyl)-5-hydroxybenzo[d][1,3]oxathiol-2-one (CAS 327078-55-7)
- 2947AF 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-3-carboxylic acid 912770-34-4 C12H7ClN2O2S (CAS 912770-34-4)
Recommended Standards
- 2-Chloro-N-isopropyl-5-nitrobenzenesulfonamide (CAS 90561-64-1)
- 2-Chloro-N-(4-methoxy-3-sulfamoylphenyl)acetamide (CAS 792953-75-4)
- 4-Chloro-3-nitro-N-propylbenzenesulfonamide (CAS 43041-68-5)
- 2-Chloroethyl N-(phenylsulfamoyl)carbamate (CAS 87708-04-1)
- L-Citrulline D2 (CAS 1021439-17-7)
- 5-amino-2-chloro-pyrimidine-4-carboxamide (CAS 189747-29-3)
- 4-(2-Amino-1,3-thiazol-4-yl)-5-methylfuran-2-carboxamide (CAS 1306605-46-8)
- tert-Butyl 3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)bicyclo[1.1.1]pentan-1-yl)azetidine-1-carboxylate (CAS 2826264-08-6)
- 2-Ethyl-2-methylheptanoic acid (CAS 31080-38-3)
- Rel-2-(benzo[b]thiophen-4-yl)-N-methyl-N-((1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl)acetamide (CAS 111728-01-9)
- 1-Methyl-3-butylimidazolium Trifluoroacetate (CAS 174899-94-6)
- 8-Amino-4-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 1888883-86-0)
- 1-(4-Oxo-4,5,6,7-tetrahydro-3H-cyclopenta[d]pyrimidin-2-yl)piperidine-4-carboxylic acid (CAS 1082512-27-3)
- Semaglutide (CAS 910463-68-2（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com