Naproxen Impurity N2 CAS 80336-62-5
| CAS No. | 80336-62-5 |
| Molecular Formula | C14H12Br2O2 |
| Molecular Weight | 372.05 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 372.05 g/mol gives Naproxen Impurity N2 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Naproxen Impurity N2 (CAS 80336-62-5) is a certified pharmaceutical impurity reference standard with the molecular formula C14H12Br2O2 and a molecular weight of 372.05 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, a polycyclic aromatic system, Naproxen Impurity N2 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 372.05 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H12Br2O2 |
| Molecular Weight | 372.05 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Br-containing |
Related Naproxen Standards
- Naproxen Impurity 43 (CAS CATO-C4X-170843)
- Naproxen Impurity 44 (CAS 90494-58-9)
- Naproxen EP Impurity D (CAS 116883-61-5)
- Naproxen EP Impurity D (CAS 116883-62-6)
- Naproxen Impurity 33 (CAS CATO-C4X-170833)
- (R)-Naproxen Acyl-β-D-glucuronide (CAS 112828-15-6)
- (S)-Naproxen Acyl-beta-D-glucuronide (CAS 41945-43-1)
- (S)-Naproxen Iso-acyl-β-D-glucuronide (CAS 219476-92-3)
Recommended Standards
- Bithionol sulfoxide (CAS 844-26-8)
- 4-(3-Bromo-4-fluorophenyl)-3-(4-nitro-1,2,5-oxadiazol-3-yl)-1,2,4-oxadiazol-5(4H)-one (CAS 2019140-71-5)
- 4,4'-Dibromo-3,3'-dimethoxy-1,1'-biphenyl (CAS 6161-47-3)
- 4-Bromo-2-(((5-bromo-3-methylpyridin-2-yl)amino)methyl)phenol (CAS 298215-64-2)
- Ibrutinib Impurity 189 (CAS CATO-C4X-1064189)
- Crizotinib Impurity 01 (CAS 877399-51-4)
- Tamsulosin Impurity 78 (CAS CATO-C4X-118778)
- 1-Chloro-n-(cyclopropylmethyl)-n-methylmethanesulfonamide (CAS 1339857-36-1)
- N-(2-Ethylphenyl)-3-(morpholinosulfonyl)benzamide (CAS 903351-16-6)
- O-Phenylhydroxylamine hydrochloride (CAS 4846-21-3)
- 6-Ethyl-5-(3-nitro-4-(piperidin-1-yl)phenyl)pyrimidine-2,4-diamine (CAS 104484-42-6)
- 6-Benzyl-2-(methylsulfonyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine (CAS 1330752-65-2)
- sec-Butyl[(2E)-3-phenyl-2-propen-1-yl]amine hydrochloride (CAS 1159698-17-5)
- Glucagon (1-29) (CAS 16941-32-5)
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