Milrinone Impurity 9 CAS 80442-07-5
| CAS No. | 80442-07-5 |
| Molecular Formula | C14H14N2O3 |
| Molecular Weight | 258.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Milrinone Impurity 9 (C14H14N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Milrinone Impurity 9 (CAS 80442-07-5, C14H14N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H14N2O3 |
| Molecular Weight | 258.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 2 |
Related Milrinone Standards
- Milrinone Impurity 30 (CAS CATO-C4X-109130)
- Milrinone impurity 38 (CAS CATO-C4X-109138)
- Milrinone Impurity 15 (CAS CATO-C4X-109115)
- Milrinone Impurity 16 (CAS 2244529-59-5)
- Milrinone Impurity 17 (CAS CATO-C4X-109117)
- Milrinone Impurity 26 (CAS CATO-C4X-109126)
- Milrinone Impurity 32 (CAS CATO-C4X-109132)
- Milrinone impurity 42 (CAS CATO-C4X-109142)
Recommended Standards
- 2-(4-(2-nitro-ethyl)-benzyloxy)-pyridine 936342-27-7 (CAS 936342-27-7)
- Ambrisentan Impurity 7 (CAS CATO-C4X-12467)
- 79410-20-1 Kemp inverted exclamation mark s triacid cis,cis-1,3,5-Trimethylcyclohexane-1,3,5-tricarboxylic acid (CAS 79410-20-1)
- Mianserin Impurity 105 (CAS CATO-C4X-1369105)
- Atrasentan Impurity 211 (CAS CATO-C4X-3347211)
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