(S)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-ol CAS 80446-59-9
| CAS No. | 80446-59-9 |
| Molecular Formula | C9H9F3O2 |
| Molecular Weight | 206.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (S)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-ol.
(S)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-ol (CAS 80446-59-9), molecular formula C9H9F3O2 and molecular weight 206.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (S)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-ol (C9H9F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9F3O2 |
| Molecular Weight | 206.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related S Standards
- 2-(1,1,1-Trifluoro-2-methylpropan-2-yl)-4H-pyran-4-one (CAS 1357476-64-2)
- 4-(1,1,1-Trifluoro-2-hydroxypropan-2-yl)phenol (CAS 179632-68-9)
- (R)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethan-1-ol (CAS 80446-58-8)
- 2,2,2-Trifluoro-1-(2-methoxypyridin-3-yl)ethanamine (CAS 1060807-17-1)
- 2,2,2-trifluoro-1-(6-methoxypyridin-2-yl)ethan-1-amine (CAS 1060807-19-3)
- 2,2,2-Trifluoro-1-(6-methoxypyridin-3-yl)ethan-1-amine (CAS 1060807-22-8)
- 2,2,2-trifluoro-1-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethan-1-one (CAS 1306606-56-3)
- 2,2,2-trifluoro-1-[1-(propan-2-yl)-1H-pyrazol-4-yl]ethan-1-one (CAS 1342725-36-3)
Recommended Standards
- (R,E)-4-(Furan-2-yl)-2-(trifluoromethyl)but-3-en-1-ol (CAS 2707491-08-3)
- [4,4'-Bipyrimidine]-2,2',6(1H,3H,3'H)-trione (CAS 35612-19-2)
- 1-(2-(Trifluoromethoxy)phenyl)ethanol (CAS 910442-37-4)
- (R)-1-(4-(Trifluoromethyl)phenyl)ethane-1,2-diol (CAS 255733-11-0)
- 5-Bromo-2-chloroaniline (CAS 60811-17-8)
- (2-Methoxyquinolin-3-yl)methanol (CAS 1038969-22-0)
- 2-([1,1'-Biphenyl]-3-yl)pyrrolidine (CAS 914299-84-6)
- (2S)-2-Amino-3-(1-(tert-Butoxycarbonyl)piperidin-3-yl)propanoic acid (CAS 1217514-76-5)
- 4-(tert-Butyl)3-methyl(S)-6,6-dimethylmorpholine-3,4-dicarboxylate (CAS 1439922-08-3)
- 2-Amino-N-((3-benzyl-1,2,4-oxadiazol-5-yl)methyl)acetamide hydrochloride (CAS 1435803-73-8)
- 1,1-Dimethylethyl N-[[4-(aminomethyl)cyclohexyl]methyl]carbamate (CAS 174959-91-2)
- 3-(α-Methylbenzyl) Saligenin (CAS 94001-67-9)
- 4-(4-Methanesulfonylphenoxy)aniline (CAS 284462-84-6)
- Biotinyl-Neuropeptide W-23 (human) (CAS 1815618-09-7)
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